End-to-End Biocatalysis Process Lead

Cascade Bio; Denver (CO); On-site; USD 130,000 - 170,000; Full time

Job summary

Cascade Biocatalysts in Denver, CO, is seeking a hands-on Process Development Scientist to build and lead our process development function, from bench-scale proof of concept to commercial-scale processes. You will own technical direction, SOPs, and cost-focused scale-up strategies, shaping the company’s science and culture.

You will work closely with the founding team, translating bottlenecks into enzyme engineering targets and mentoring a growing team in a fast-paced, early-stage environment.

Qualifications

• PhD or MS with catalysis/biocatalysis focus and bench-to-commercial scale experience.
• Demonstrated ability to improve process performance toward commercial targets.
• Experience with techno-economic modeling and PAT tools.
• Comfort using data-driven decision making across disciplines.

Responsibilities

• Own process development end-to-end from bench to scalable processes.
• Run and optimize enzymatic reactions and intensify processes.
• Collaborate with enzyme immobilization and evaluate catalyst formats.
• Lead and grow a process development team over time.
• Build techno-economic models and assess impact on cost and yield.
• Interface with protein engineering to address bottlenecks.
• Contribute across the organization with cross-functional communication.

Skills

Process development

Scale-up

Techno-economic modeling

DOE-driven development

Cross-disciplinary collaboration

Analytical chemistry

Engineering interface

Education

PhD in biochemistry

MS in chemical engineering

Tools

Process analytical tools

DOE software

Job description

Cascade Biocatalysts in Denver, CO, is seeking a hands-on Process Development Scientist to build and lead our process development function, from bench-scale proof of concept to commercial-scale processes. You will own technical direction, SOPs, and cost-focused scale-up strategies, shaping the company’s science and culture.

You will work closely with the founding team, translating bottlenecks into enzyme engineering targets and mentoring a growing team in a fast-paced, early-stage environment.