E4A Systemic Mastocytosis/Emerging Indication HEOR Strategy Specialist

Sanofi; Cambridge (MA); On-site; USD 149,000 - 215,000; Full time

Benefits offered by this job

Health benefits

Parental leave

Career growth

Job summary

Sanofi's HEVA team in Cambridge, MA is seeking a Systemic Mastocytosis/Emerging Indication HEOR Strategy Specialist to lead US-focused HEOR for AYVAKIT and new assets. You will design economic models, conduct RWE studies, and prepare payer dossiers to support US access and reimbursement.

This role partners with US Medical Affairs, Value & Access, and Policy teams, translating global evidence into US value narratives while mentoring junior colleagues and contributing to cross-functional planning.

Qualifications

• Advanced degree (PhD/PharmD) in health economics or related field, or Master’s with ≥4–5 years HEOR experience.
• 2+ years in health economics, outcomes research, or related field; fellowship preferred.

Responsibilities

• Lead US-focused HEOR for AYVAKIT and emerging assets; design/evaluate US HEOR plans.
• Institute economic models, database analysis, RWE studies, and evidence synthesis.
• Develop payer dossiers and support US access and policy strategies.
• Collaborate with US Medical Affairs, Value & Access, Policy; mentor juniors.

Skills

HEOR

Research design

Communication

Project management

Education

PhD/PharmD or equivalent in health economics

Master's + 4-5 years HEOR experience

Tools

AI tools

Data analytics platforms

Job description

E4A Systemic Mastocytosis/Emerging Indication HEOR Strategy Specialist

Location: Cambridge, MA

About the Job

HEVA's mission is to conduct, communicate, and translate evidence to demonstrate the value of Sanofi's products and support optimal access and treatment outcomes for patients.

HEVA Vision, Mission, and Values We are one bold HEOR team leveraging innovative HEOR to transform patient care and access. As HEOR experts, we lead the generation and dissemination of robust, business-relevant evidence to demonstrate value and drive access to medicines. The HEVA organization is driven by five core values that define how we work and deliver impact. We operate as One Team, partnering without boundaries while pursuing a Bold Purpose through ambitious, measurable goals. Grounded in Scientific Excellence with Relevance and deep technical expertise, we embrace Innovation in Action to transform how we research and deliver Impact for People, creating meaningful outcomes for patients, the healthcare ecosystem, and our colleagues who make it all possible. Join the team transforming care for people with immune challenges, rare diseases, cancers, and neurological conditions. In Specialty Care, you’ll help deliver breakthrough treatments that bring hope to patients with some of the highest unmet needs.

About Sanofi We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system - and innovative pipeline - enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities

This role will lead US-focused Health Economic and Outcomes Research activities for AYVAKIT® in Systemic Mastocytosis and emerging pipeline assets within the US Rare/Oncology HEVA team, providing US insights and executional leadership while remaining aligned to - but not accountable for - global HEVA strategy. Lead the design and execution of US-focused HEOR for AYVAKIT® (avapritinib) in Systemic Mastocytosis and assigned emerging assets - including economic modelling, database analysis, observational research, RWE studies, systematic literature review, evidence synthesis, and AMCP dossier development - setting US evidence generation priorities and incorporating them into broader Sanofi planning documents such as the Integrated Evidence Generation Plan (IEGP); operate with medium independence for strategic work and high independence for tactical execution, consistent with L3-2 expectations. Translate HEVA evidence into US business and policy impact by driving payer engagement, value positioning, and access strategies for AYVAKIT® in the US marketplace; understand and address US payer evidence requirements across managed care, specialty pharmacy, and rare disease payer dynamics; and support the development of compliant and impactful US evidence dissemination pathways (e.g., HCEI, PIE, CFL) including payer dossiers, field materials, and publications. Operate as part of a multi-functional US brand team responsible for designing research programs to meet the evidentiary standards of US reimbursement authorities and third-party payers; provide recommendations to ensure clinical and real-world evidence programs support US payer differentiation and value demonstration; and contribute to cross-functional US planning processes including brand planning, lifecycle management, and launch readiness for AYVAKIT® and pipeline assets. Serve as the US HEVA representative within the broader global HEVA team, ensuring the US perspective is well represented in global IEGPs, clinical development programs, and market access strategies; translate global evidence packages into US-specific value narratives and payer-facing materials; and engage with ICER review processes and the US policy landscape as relevant to Systemic Mastocytosis and emerging assets. Partner with US Medical Affairs, Value & Access, and Policy teams to ensure appropriate use of HEOR evidence in field communications, payer engagement, and training; collaborate on evidence that informs value frameworks, PDAB and ICER responses, and value-based contracting strategies; and mentor junior colleagues on a case-by-case basis, sharing US HEOR and market access expertise.

About You

Basic Qualifications

• Education: Advanced degree (PhD, PharmD, or equivalent) in health economics, epidemiology, public health, economics, or a related field; or Master's degree in a related field + minimum 4-5 years of relevant HEOR/outcomes research experience
• Experience: Completion of a relevant fellowship or minimum of 2+ years of experience in health economics, outcomes research, or a related field

Technical Skills

• Foundational knowledge in health economic modeling, real-world evidence generation, evidence synthesis, and outcomes research methodologies.
• Understanding of global health technology assessment processes and payer decision-making frameworks.
• Foundational knowledge of AI and digital tools relevant to health economics, including familiarity with data analytics platforms and digital research tools; demonstrated willingness to rapidly develop proficiency with new digital and AI-enabled solutions.

Soft Skills

• Strong written and verbal communication skills with ability to present technical information clearly to diverse audiences.
• Good project management skills with ability to manage timelines and deliverables while staying on budget.
• Entrepreneurial spirit, team orientation, and ability to develop creative solutions to complex problems.

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team
• Discover opportunities to grow your talent and drive your career, whether through a promotion or lateral move, at home or internationally
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs, and at least 14 weeks' gender-neutral parental leave

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affiliated Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

North America Applicants Only

Salary range for this position is: $148,500.00 - $214,500.00 All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here. We are an R&D driven, AI-powered biopharma company committed to improving people's lives and creating compelling growth. Our team is guided by one purpose: we chase the miracles of science to improve people’s lives. We want to build a healthier, more resilient world, and turn the impossible into the possible by discovering, developing, and delivering medicines and vaccines for millions of people around the world. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi Start a career that makes a difference. Reinvention is in our DNA. It's what drove our evolution from a small French enterprise to one of the world's leading biopharma companies. Whether it's using AI to shorten drug-discovery times or building trust in healthcare, you could be helping our teams make life better for patients, partners, and communities. This is where you grow your career. We open the door for you to explore new opportunities, push your limits, and connect with people who are driven by a shared purpose: we chase the miracles of science to improve people's lives.