DNA Development Scientist - Gene Therapy

Asklepios Biopharmaceutical Inc; Durham (NC); On-site; USD 150,000 - 190,000; Full time

Job summary

AskBio Inc. seeks a PhD-level DNA Development Scientist to optimize DNA manufacturability and quality for rAAV production. You will design and test DNA constructs and serve as technical consultant for CMC activities, regulatory strategies, and process transfer.

Based in RTP, NC, you will mentor teammates, lead collaborations with CMDO and QA teams, conduct hands-on experiments, and prepare regulatory-ready documentation while upholding our rigorous safety and quality standards.

Qualifications

• PhD (Molecular Biology, Genetics, Virology) with 5+ years of relevant work experience or MS with 10+ years.
• Expertise in viral gene therapy, including recombinant AAV systems.
• Strong understanding of DNA replication in bacteria and rAAV production in mammalian culture.

Responsibilities

• Independently design and execute projects to improve DNA manufacturability and quality.
• Lead collaborations to transfer DNA processes into manufacturing.
• Serve as technical consultant on DNA starting materials for CMC and regulatory activities.
• Author technical and development documents and present data in forums.
• Mentor team members and maintain safe, compliant lab practices.

Skills

DNA design

rAAV production

Molecular biology

Data analysis

Regulatory docs

Education

PhD in Molecular Biology

MS in Molecular Biology

Tools

AKTA systems

Fermenters/bioreactors

SnapGene

PCR/cloning

Job description

AskBio Inc. seeks a PhD-level DNA Development Scientist to optimize DNA manufacturability and quality for rAAV production. You will design and test DNA constructs and serve as technical consultant for CMC activities, regulatory strategies, and process transfer.

Based in RTP, NC, you will mentor teammates, lead collaborations with CMDO and QA teams, conduct hands-on experiments, and prepare regulatory-ready documentation while upholding our rigorous safety and quality standards.