DMPK Scientist

Schrödinger; San Diego (CA); On-site; USD 170,000 - 290,000; Full time

Benefits offered by this job

Healthcare (dental & vision)

401k

Pre-tax commuter benefits

Flexible work schedule

Parental leave

Job summary

Schrödinger seeks a DMPK Scientist in San Diego to lead ADME and PK/PD strategy across drug discovery programs. You will partner with cross-functional teams to turn molecular modeling insights into druggable candidates and drive data-driven decisions.

The role requires a PhD or advanced degree with extensive DMPK experience, hands-on PK/PD modeling, and expertise with software tools such as Phoenix/WinNonlin, SimCYP, Monolix or MATLAB SimBiology.

Qualifications

• PhD or Master’s with extensive DMPK experience in pharma.
• Independent experience representing DMPK on project teams.

Responsibilities

• Develop and drive DMPK and PK/PD strategies for drug discovery projects.
• Represent the DMPK group on internal and intercompany project teams to turn ideas into druggable candidates.
• Collaborate with CROs and internal teams to generate data for knowledge integration.
• Analyze and integrate in silico ADME, physicochemical, ADME and DMPK data for multiparameter optimization.
• Author/review regulatory submission reports and support interactions with regulators.
• Collaborate on predictive computational ADME/DMPK models.

Skills

ADME principles

PK/PD modeling

Data analysis

Scientific communication

DMPK expertise

Education

PhD in life sciences/related field

Master’s degree in life sciences/related field

Tools

Phoenix/WinNonlin

SimCYP

Monolix

MATLAB SimBiology

Job description

We’re seeking a DMPK Scientist to join us in our mission to transform the discovery of therapeutics!

Our drug discovery and preclinical development team includes a cross-functional group of scientists and drug developers with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers, as well as a large-scale compute infrastructure to apply our proprietary physics based drug design and optimization platform. Ten of the programs we’ve worked on have progressed into preclinical development, with nine currently in clinical trials and one approved by the FDA.

Who Will Love This Job

• A DMPK analysis expert, who understands ADME principles and applications throughout drug development applications throughout drug discovery and development
• A scientist with a robust background in DMPK who has specialized in the use and application of any of the following:
• In vitro/in vivo drug metabolism or transporter approaches to identify potential ADME liabilities and aid in compound optimization
• PK/PD and PBPK modeling approaches to optimize compound selection, dose optimization, and study design (this includes experience with commonly-used PK/PD software, such as Phoenix/WinNonlin, SimCYP, Monolix, MATLAB SimBiology, or other equivalent software)
• A proven Principal Investigator and scientific strategist who’s self-driven and results-oriented
• A highly motivated, self-driven, and results-oriented data-analyzer
• An excellent communicator and presenter who can work both as a team player and a project driver
• A flexible, curious scientist who’s excited about networking and building internal and external relationships

What You Will Do

• Develop and drive DMPK and PK/PD strategy for drug discovery projects
• Represent the DMPK group on internal and intercompany project teams to help turn molecular modeling design ideas into druggable novel chemical entities
• Collaborate with internal and intercompany project team members and external CROs to generate relevant data to enable knowledge and data integration
• Analyze and integrate in silico ADME predictive solutions, physicochemical, ADME, and DMPK data to impact multiparameter optimization
• Author and/or review appropriate reports for regulatory submission of development drug candidates and ensure the overall quality of the studies and interpretation (this entails supporting interactions with regulatory agencies)
• Collaborate with scientific development team on establishment of predictive computational ADME/DMPK models

What You Should Have

• PhD in life sciences, chemical engineering, pharmacokinetics, pharmaceutical sciences, or a related discipline with at least five years of experience working with DMPK in the pharmaceutical industry or Master’s degree in life sciences, chemical engineering, pharmacokinetics, pharmaceutical sciences, or a related discipline with at least ten years of experience working with DMPK in the pharmaceutical industry
• Prior experience independently representing DMPK on project teams

Pay And Perks

Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program.

We have a company culture that is relaxed, but engaged, and over a month of paid vacation time. Our Office Management team also plans a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been included in Crain's New York Best Places to Work, BuiltIn's NYC Best Place to Work, and Newsweek's list of America's 100 Most Loved Workplaces.

Estimated base salary range: $170,000 - $290,000. Actual compensation package is dependent on a number of factors, including, for example, experience, education, degrees held, market data, and business needs. If you have any questions regarding the compensation for this role, do not hesitate to reach out to a member of our Strategic Growth team.

As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.