Distinguished Scientist, Systems Toxicology

(0207) Sanofi US Services Inc.; Cambridge (MA); On-site; USD 179,000 - 258,000; Full time

Benefits offered by this job

High-quality healthcare

Prevention and wellness programs

14 weeks gender-neutral parental leave

Job summary

Sanofi in Cambridge, MA invites a Distinguished Scientist, Systems Toxicology to provide scientific leadership in applying multi-omics and systems biology to predict safety liabilities and mechanisms of toxicity, guiding experiments and informing development decisions.

You will lead cross-disciplinary analyses, mentor scientists, establish robust analytical workflows, and partner with project toxicologists and scientific advisors to translate biology into actionable insights across preclinical

Qualifications

• MS plus 8 years experience or PhD plus 5 years experience.
• Scientific expertise: Systems Biology, Computational Biology, Bioinformatics, or a related discipline, with extensive research experience and demonstrated independent leadership of complex investigations.
• Technical skills: Deep hands-on expertise in transcriptomics and demonstrated experience integrating multiple molecular or phenotypic data types.
• Computational and statistical capabilities: Strong proficiency in R and/or Python and relevant bioinformatics tools.
• Mechanistic and translational interpretation: Expertise in pathway and network analysis, molecular signatures, and hypothesis generation.
• Drug discovery and safety experience: Substantial experience applying systems approaches to toxicology, safety assessment, or closely related mechanistic research in pharmaceutical or biotechnology settings.
• Strategic mindset: Understanding of how preclinical safety data translates to human safety, ability to translate scientific vision into actionable roadmaps, connect digital toxicology to broader R&D strategy.
• Communication & influence: Ability to communicate complex analyses clearly to experimental scientists, computational specialists, project teams, and senior leaders.

Responsibilities

• Provide scientific direction for systems toxicology, defining approaches for applying omics and integrative biology to priority safety questions.
• Lead integrated analyses of complex biological datasets, connecting transcriptomics with complementary data such as proteomics, metabolomics, imaging, pathology, and functional assays.
• Generate and prioritize mechanistic hypotheses using pathway analysis, network biology, molecular signatures, and existing biological knowledge.
• Establish reproducible and scalable analytical workflows, spanning data processing, quality assessment, statistical analysis, visualization, and reporting.
• Drive cross-functional investigations across Preclinical Safety, connecting early screening, complex models, and investigative studies with molecular mechanisms.
• Provide scientific leadership across project teams and global functions, working with project toxicologists and scientific advisors to define decision-relevant questions and communicate integrated findings.
• Demonstrate scientific and portfolio impact, serving as a scientific authority and mentor across the global organization.

Skills

Systems Biology

Computational Biology

Bioinformatics

Transcriptomics

Pathway analysis

Network biology

R

Python

Data integration

Education

MS + 8 years experience or PhD + 5 years experience

Job description

Job title: Distinguished Scientist, Systems Toxicology Location: Cambridge, MA; Morristown, NJ

About the Job As Distinguished Scientist, Systems Toxicology, you will provide scientific leadership in the application of multi-omics datasets and systems biology to predict safety liabilities, investigate mechanisms of toxicity, and assess human relevance. You will connect complex molecular and phenotypic datasets to generate testable hypotheses, guide experimental investigations, and inform decisions across drug discovery and development. Strong knowledge of regulatory safety requirements in the field of pharmaceutical drug development is also necessary. Natural strengths in networking and communication are also essential. Within Toxicology Innovation, you will shape the scientific direction of omics-based safety assessment and lead the development of robust analytical workflows. Working across Toxicology Innovation, and in partnership with project toxicology and scientific advisors, you will translate biological questions into integrated analyses and actionable scientific insights. This is a senior, hands‑on individual contributor position with global scientific influence. You will lead complex investigations, establish analytical approaches and standards, mentor scientists across disciplines, and build capabilities that strengthen safety assessment across the portfolio.

Sanofi's Preclinical Safety department is a global, science-driven organization committed to delivering innovative, data-informed safety assessments that support the development of life-changing medicines. The Global Toxicology Innovation group sits at the intersection of computational science, biology, and drug development — pioneering new approaches to toxicity prediction, mechanistic understanding, and clinical translatability.

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main responsibilities:

• Provide scientific direction for systems toxicology, defining approaches for applying omics and integrative biology to priority safety questions.
• Lead integrated analyses of complex biological datasets, connecting transcriptomics with complementary data such as proteomics, metabolomics, imaging, pathology, and functional assays.
• Generate and prioritize mechanistic hypotheses using pathway analysis, network biology, molecular signatures, and existing biological knowledge.
• Establish reproducible and scalable analytical workflows, spanning data processing, quality assessment, statistical analysis, visualization, and reporting.
• Drive cross-functional investigations across Preclinical Safety, connecting early screening, complex models, and investigative studies with molecular mechanisms.
• Provide scientific leadership across project teams and global functions, working with project toxicologists and scientific advisors to define decision-relevant questions and communicate integrated findings.
• Demonstrate scientific and portfolio impact, serving as a scientific authority and mentor across the global organization.

About You To succeed in this role, you will bring a rare combination of deep expertise in systems biology and omics, strong toxicological judgement, and a sustained record of translating complex data into mechanistic understanding and meaningful project impact. You combine scientific independence with hands‑on analytical capability and the ability to build productive partnerships across disciplines.

Minimum Requirements:

• MS plus 8 years experience or PhD plus 5 years experience
• Scientific expertise: Systems Biology, Computational Biology, Bioinformatics, or a related discipline, with extensive research experience and demonstrated independent leadership of complex investigations.
• Technical skills: Deep hands‑on expertise in transcriptomics and demonstrated experience integrating multiple molecular or phenotypic data types.
• Computational and statistical capabilities: Strong proficiency in R and/or Python and relevant bioinformatics tools.
• Mechanistic and translational interpretation: Expertise in pathway and network analysis, molecular signatures, and hypothesis generation.
• Drug discovery and safety experience: Substantial experience applying systems approaches to toxicology, safety assessment, or closely related mechanistic research in pharmaceutical or biotechnology settings.
• Strategic mindset: Understanding of how preclinical safety data translates to human safety, ability to translate scientific vision into actionable roadmaps, connect digital toxicology to broader R&D strategy.
• Communication & influence: Ability to communicate complex analyses clearly to experimental scientists, computational specialists, project teams, and senior leaders.

Why Choose Us

Bring the miracles of science to life alongside a supportive, future-focused team.

Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

Enjoy a thoughtful, well‑crafted rewards package that recognizes your contribution and amplifies your impact. Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender‑neutral parental leave.

Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real‑world needs. Help improve the lives of millions of people globally by making drug development quicker and more effective. Work at the forefront of drug discovery, harnessing cutting‑edge AI, data, and digital platforms to push the boundaries of science.

Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. #GD-SA #LI-SA #vhd #LI-Hybrid

Sanofi US endeavours to make our career center accessible to any and all users.

All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

US and Puerto Rico Residents Only Sanofi Inc. and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

North America Applicants Only The salary range for this position is: $178,500.00 - $257,833.33

All compensation will be determined commensurate with demonstrated experience.

Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

We are an R&D driven, AI-powered biopharma company committed to improving people’s lives and creating compelling growth.

Our team is guided by one purpose: we chase the miracles of science to improve people’s lives. We want to build a healthier, more resilient world, and turn the impossible into the possible by discovering, developing, and delivering medicines and vaccines for millions of people around the world.

Discover more about us visiting www.sanofi.com or via our movie We are Sanofi Start a career that makes a difference. Reinvention is in our DNA. It’s what drove our evolution from a small French enterprise to one of the world’s leading biopharma companies. Whether it’s using AI to shorten drug-discovery times or building trust in healthcare, you could be helping our teams make life better for patients, partners, and communities. This is where you grow your career. We open the door for you to explore new opportunities, push your limits, and connect with people who are driven by a shared purpose: we chase the miracles of science to improve people’s lives.