Distinguished Scientist, Discovery-Oncology

6084-Janssen Research & Development, LLC Legal Entity; Spring House (PA); On-site; USD 180,000 - 250,000; Full time

Job summary

Johnson & Johnson Innovative Medicine Oncology Discovery seeks a Distinguished Scientist to lead a cross-disciplinary team focused on engineering and optimizing T-cell engagers (TCEs) and small-molecule therapeutics for prostate cancer at Spring House, PA. You will drive a robust platform and mentor scientists in a highly collaborative environment.

The role requires a PhD in Cancer Biology or Immunology with 12+ years of industry leadership, plus hands-on large-molecule experience, assay

Qualifications

• Ph.D. in Cancer Biology and/or Immunology with 12+ years of industry leadership.
• Hands-on experience with large molecules and IND-enabling activities.
• Proven ability to lead cross-functional teams and drive portfolio programs.
• Experience recruiting, developing, and retaining top scientific talent.

Responsibilities

• Lead a team of scientists in nominating T-cell engagers (TCE) and costimulatory molecules for the treatment of prostate cancer.
• Lead a team of scientists to develop state-of-the-art assays that enable the identification of optimal TCE candidates to maximize therapeutic potential and durability in solid tumors.
• Foster a culture of scientific excellence and innovation that lead to next generation TCE/costim platforms.
• Partner with leaders in other therapeutic areas to select optimal binders, molecular configuration and delivery strategies.
• Organize business development and diligence efforts with internal and external partners to pursue opportunities associated with next gen TCE or small molecule therapies.
• Eliminate barriers to collaboration across workstreams and functions by encouraging a culture of open communication and transparency.
• Contribute to intellectual property, public presentations, and manuscript writing.
• Identify partnerships in academia to compliment key research initiatives.
• Mentor scientists on the team, and promote personal and professional development.
• Contribute to leadership of PDAS discovery team by crafting the overall strategy of efforts across the various workstreams.

Skills

Leadership

Cross-functional collaboration

Verbal and written communication

Matrixed leadership

Education

Ph.D. in Cancer Biology or Immunology

Tools

Large molecule drug development

Job description

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow,and profoundly impact health for humanity.Learn more at jnj.com. As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit. Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function: Pharmaceutical Product R&D Job Category: Scientific/Technology All Job Posting Locations: Spring House, Pennsylvania, United States of America Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. About Oncology Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. We are searching for the best talent for a Distinguished Scientist, in Oncology Discovery, Innovative Medicine, located in Spring House, PA. Johnson & Johnson Innovative Medicine Oncology Discovery seeks an outstanding and highly motivated leader to join our team focused on creating best-in-class therapeutics for prostate cancer treatment. This position will lead a cross-disciplinary team responsible for developing a robust platform to engineer and optimize T-cell engagers (TCEs), and small molecule therapeutics. Candidates should have expertise in cancer biology or immunology, and the mechanisms required to trigger robust anti-tumor response. Additionally, candidates must demonstrate direct experience in small/large molecule design and/or combination strategies to overcome solid tumor microenvironment. Furthermore, knowledge of current assays required to characterize optimal T-cell functional performance is a requirement. A successful candidate is expected to drive future innovation around TCE design by identifying enabling technologies through either internal or external efforts. Candidates must demonstrate prior program leadership experience in industry and must have a track record of excellence in managing teams and developing scientific talent.

The Distinguished Scientist will:

• Lead a team of scientists in nominating T-cell engagers (TCE) and costimulatory molecules for the treatment of prostate cancer
• Lead a team of scientists to develop state-of-the-art assays that enable the identification of optimal TCE candidates to maximize therapeutic potential and durability in solid tumors
• While delivering on prioritized goals, foster a culture of scientific excellence and innovation that lead to next generation TCE/costim platforms
• Partner with leaders in other therapeutic areas to select optimal binders, molecular configuration and delivery strategies
• Organize business development and diligence efforts with internal and external partners to pursue opportunities associated with next gen TCE or small molecule therapies
• Eliminate barriers to collaboration across workstreams and functions by encouraging a culture of open communication and transparency
• Contribute to intellectual property, public presentations, and manuscript writing
• Identify partnerships in academia to compliment key research initiatives
• Mentor scientists on the team, and promote personal and professional development
• Contribute to leadership of PDAS discovery team by crafting the overall strategy of efforts across the various workstreams

Qualifications

• Demonstrate strong matrixed leadership behavior and capabilities including: the ability to influence and collaborate with peers, develop and mentor team scientists, and coordinate work of colleagues to achieve meaningful outcomes and build business impact.
• Ph.D. in Cancer Biology and/or Immunology with at least 12+ years of industry experience leading portfolio programs and teams.
• Hands-on experience with large molecules and a track record of successfully advancing large molecule candidates through lead selection and IND-enabling activities.
• Possession of knowledge with regards to large molecule drug development.
• Demonstrable track record of innovating in the large molecule space.
• Constantly seek new technologies, processes, and techniques.
• Able to integrate diverse subject areas to achieve research objectives.
• Experience recruiting, developing, and retaining top talent and building strong teams which are highly productive and efficient.
• Experience supporting research collaborations with academic institutions, industry partners and research institutions.
• Understanding of how to partner with legal resources and business development teams to build IP strategies, collaborate with external partners and identify FTO opportunities.
• Fosters highly collaborative, multi-disciplinary team settings, and possesses highly effective verbal and written communication skills.
• Ability to apply forward-thinking strategy while also delivering on key objectives for near-term projects.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.

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Required Skills: Preferred Skills: Budget Management, Chemistry, Manufacturing, and Control (CMC), Clinical Trial Protocols, Consulting, Design Mindset, Drug Discovery Development, Good Governance, Industry Analysis, Interdisciplinary Work, Market Research, Presentation Design, Process Improvements, Product Development, Product Licensing, Product Strategies, Risk Management, Scientific Research At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow,and profoundly impact health for humanity.Learn more at https://www.jnj.com/.

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