Display Technologies Scientist I — Antibody Discovery & ML

BigHat; San Mateo (CA); On-site; USD 120,000 - 145,000; Full time

Benefits offered by this job

Bonus

Stock options

Benefits package

Job summary

BigHat Biosciences seeks a Scientist I to join the Display Technologies team in a full-time capacity at San Mateo. You will contribute to antibody discovery and engineering, generating high-quality data to improve ML models using display technologies, working with senior scientists and cross-functional teams.

The role requires strong molecular biology skills, knowledge of display platforms, and a collaborative startup mindset to drive experiments from design to data-driven conclusions.

Qualifications

• Ph.D. in Biochemistry, Structural Biology, Protein Engineering, or related field; up to 2 years industry research; or MS with 6+ years industry experience.
• Experience with display technologies, including library design and selection strategies.
• Knowledge of antibody biology and protein expression.
• Strong molecular biology techniques (PCR, cloning, gel electrophoresis).
• Good documentation, ability to troubleshoot, and maintain detailed lab records.

Responsibilities

• Support R&D projects advancing display technologies and feed ML models.
• Lead construction and QC of phage display libraries for various antibody formats.
• Execute phage display selections to engineer antibodies with desired properties.
• Express, purify, and characterize display-derived molecules using ELISA, flow cytometry, BLI/SPR, CE-SDS.
• Analyze selection results and help plan future experiments.
• Collaborate with Data Science to design libraries and interpret data for models.
• Coordinate with leadership to align strategy, research, and development.
• Present plans and results in regular team meetings.
• Communicate results to key decision makers and external partners.

Skills

Display technologies experience

Antibody biology knowledge

Molecular biology techniques

Data analysis

Clear written and verbal communication

Team collaboration

Publication record

Problem solving

Time management

Education

Ph.D. in Biochemistry/Structural Biology/Protein Engineering

M.S. in a related field with 6+ years industry experience

Tools

LIMS

Phage display/library design

BLI/SPR

NGS platforms familiarity

Job description

BigHat Biosciences seeks a Scientist I to join the Display Technologies team in a full-time capacity at San Mateo. You will contribute to antibody discovery and engineering, generating high-quality data to improve ML models using display technologies, working with senior scientists and cross-functional teams.

The role requires strong molecular biology skills, knowledge of display platforms, and a collaborative startup mindset to drive experiments from design to data-driven conclusions.