Discovery Postdoctoral Fellow in Neuroscience

Scorpion Therapeutics; Cambridge (MA); On-site; USD 78,000 - 96,000; Full time

Benefits offered by this job

Health benefits

401(k) with company matching

Generous time off

Job summary

Scorpion Therapeutics in Cambridge, MA seeks a Discovery Postdoctoral Fellow to lead an independent research program using human iPSC-derived neurons and glia.

The role focuses on multi-omics integration to map neuronal networks affected by disease in ALS and Alzheimer’s, with collaboration across research units and opportunities for high-impact publications.

Qualifications

• PhD (completed before fellowship start; 2026 conferral acceptable)
• Strong publications, presentations, or patents or equivalent achievements
• Expertise in neurobiology and molecular/cell biology or biochemistry
• Experience with human iPSC-derived neuronal or glial models
• Experience with confocal microscopy and high-content imaging/analysis
• Ability to analyze complex proteomics datasets

Responsibilities

• Design and conduct an independent, hypothesis-driven research program
• Develop and apply human iPSC-derived neuron and glia models
• Utilize genomics, proteomics, and transcriptomics approaches
• Analyze and integrate multi-omics datasets
• Collaborate with interdisciplinary teams across research units
• Communicate findings through presentations and publications

Skills

Neurobiology

Molecular biology

Biochemistry

Confocal microscopy

High-content imaging

Proteomics

Multi-omics analysis

Education

PhD in neuroscience or related field

Tools

Confocal microscopy

Halo µMapping

High-content imaging systems

Job description

Internal Job Title: Discovery Postdoctoral Fellow

Position Location: Cambridge, MA (onsite)

Key Responsibilities:

• Design and execute an independent, hypothesis-driven research program
• Develop and apply human iPSC-based neuron and glial models
• Utilize genomics, proteomics, and transcriptomics approaches
• Analyze and integrate multi-omics datasets
• Collaborate with interdisciplinary teams across research units
• Communicate findings through presentations and peer-reviewed publications

Research Opportunity:

• Map early neuronal TDP-43 interaction networks influenced by disease-associated glial environments in ALS and Alzheimer’s to identify shared, druggable targets
• Leverage human iPSC-derived neuron–glia systems, proteomics, transcriptomics, and multi-omics integration to study neuronal vulnerability and disease progression

Essential Requirements:

• PhD (or equivalent) in neuroscience, biology, or related discipline (completed prior to fellowship start date; PhD conferred in 2026 only)
• Demonstrated scientific achievement (publications, presentations, patents, or equivalent)
• Strong expertise in neurobiology, molecular/cell biology, or biochemistry
• Strong commitment to learning, innovation, and professional development
• Experience with human iPSC-derived neuronal or glial models
• Experience with confocal microscopy and high-content imaging/analysis
• Ability to analyze complex proteomics datasets

Desirable Requirements:

• Expertise in TDP-43 or apolipoprotein E biology and mechanisms of neurodegeneration
• Experience with protein interactome mapping (Halo µMapping) or chemo-proteomics

Compensation/Benefits (as stated):

• Starting salary: $87,000 USD/year
• US-based eligible employees: comprehensive benefits including health, life/disability, 401(k) with company contribution/match, and other benefits; generous time off (vacation, personal days, holidays, and other leaves)