Director, Translational Pharmacokinetics - DMPK

Ladders; United States; Remote; USD 177,000 - 284,000; Full time

Benefits offered by this job

401(k) plan

Pension

Medical, dental, vision and Rx

Flexible spending accounts

Life insurance

Well-being programs and fitness

Performance-based bonus

Job summary

Ladders is seeking a Director, Translational Pharmacokinetics - DMPK to shape PK strategy across a biotech pipeline. You will build PBPK and PKPD models translating preclinical and clinical data into actionable dosing, safety, and regulatory insights, guiding first-in-human planning and submissions.

The role is remote from the US and offers a competitive compensation package. A track record in IND-enabling work, cross-functional collaboration, and senior PK/PD modeling is required.

Qualifications

• PhD, PharmD, or equivalent advanced scientific degree.
• 12+ years of industry experience in PBPK and PKPD modeling.
• Experience with IND-enabling programs and regulatory submissions.
• Solid understanding of ADME principles.
• Proficiency in pharmacokinetic modeling software such as Simcyp and GastroPlus.
• Ability to critically evaluate experimental data.
• Experience in a collaborative biotechnology environment.

Responsibilities

• Design and implement PBPK models to simulate drug behavior.
• Create and evolve PKPD models using clinical and nonclinical data.
• Support first-in-human dose projections for drug candidates.
• Integrate diverse experimental data to improve model accuracy.
• Provide simulations for regulatory submissions and decision-making.
• Collaborate with cross-functional teams to validate models.
• Conduct simulations to predict drug-drug interactions and optimize dosing strategies.

Skills

PBPK modeling

PKPD modeling

IND-enabling programs

Regulatory submissions

ADME principles

Cross-functional collaboration

PK modeling software

Simcyp

GastroPlus

Data interpretation

DMPK strategy

Education

PhD, PharmD, or equivalent advanced degree

Tools

Simcyp

GastroPlus

Job description

For our client, we are seeking a Director, Translational Pharmacokinetics - DMPK to join the team of a leader in the Pharmaceuticals & Biotech space.
This leader is seeking an experienced scientific professional to shape translational pharmacokinetic strategy and inform critical development decisions across the drug pipeline. In this role, you will build and apply PK and PKPD models that help translate preclinical and clinical data into actionable dosing, safety, and regulatory insights. You will partner closely with cross-functional development teams to support first-in-human planning, model validation, and submissions that advance programs with confidence.
Location: Remote - US based candidates only, no visa sponsorship available
Compensation: $177,000 – $283,800 annually

Responsibilities

• Design and implement PBPK models to simulate drug behavior
• Create and evolve PKPD models using clinical and nonclinical data
• Support first-in-human dose projections for drug candidates
• Integrate diverse experimental data to improve model accuracy
• Provide simulations for regulatory submissions and decision-making
• Collaborate with cross-functional teams to validate models
• Conduct simulations to predict drug-drug interactions and optimize dosing strategies

Qualifications

• PhD, PharmD, or equivalent advanced scientific degree
• 12+ years of industry experience in PBPK and PKPD modeling
• Experience with IND-enabling programs and regulatory submissions
• Solid understanding of ADME principles
• Proficiency in pharmacokinetic modeling software such as Simcyp and GastroPlus
• Ability to critically evaluate experimental data
• Experience in a collaborative biotechnology environment

Benefits

• Eligibility for a company-sponsored 401(k) and pension
• Vacation benefits
• Medical, dental, vision, and prescription drug benefits
• Flexible spending accounts for healthcare and dependent care
• Life insurance and death benefits
• Well-being benefits including employee assistance programs and fitness benefits
• Participation in company bonus programs based on performance

Our client is an equal opportunity employer. We encourage you to apply even if you don’t meet every qualification—your background could be exactly what this team needs.