Director, Therapeutics Translational Neurobiology

Broad Institute; Cambridge (MA); On-site; USD 260,000 - 380,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k)

Paid holidays

Parental leave

Job summary

The Broad Institute's Stanley Center for Psychiatric Research is seeking a Director of Therapeutics Translational Neurobiology to shape strategy, identify novel targets, and lead execution across multiple preclinical programs in schizophrenia and bipolar disorder.

Reporting to the Stanley Center co-director, you will manage a small team and collaborate with Broad's CDoT and business development to advance external partnerships.

Qualifications

• Ph.D. or M.D./Ph.D. in Neuroscience, Pharmacology, Molecular/Cell Biology, Chemistry, or a related life sciences field.
• 10+ years of drug discovery in industry with CNS/psychiatric disease focus.
• Experience managing a multi-project portfolio and leading a team; external partnerships experience.

Responsibilities

• Define and drive scientific strategy across a portfolio of several therapeutics projects.
• Oversee target validation through drug discovery and preclinical proof-of-concept.
• Mentor project leads and build a team to prosecute new targets.
• Represent the center's therapeutics work externally, including partnerships and conferences.
• Budget planning and resource allocation across programs.

Skills

Leadership

Portfolio management

Strategic planning

Scientific communication

Mentoring

Education

PhD or MD/PhD

Job description

Description & Requirements

About the Stanley Center

The Stanley Center for Psychiatric Research at the Broad Institute is a world leader in the study of bipolar disorder and schizophrenia. Founded and supported by the Stanley Family Foundation, the Stanley Center brings together experts in genetics, computation, neurobiology, and therapeutics to work in partnership to understand the biology of schizophrenia and bipolar disorder and to translate that understanding into new treatments. Our preclinical therapeutics program takes genetically and biologically grounded targets through early drug discovery to preclinical proof-of-concept, drawing on the Stanley Center's deep expertise in human genetics, iPSC-derived cellular models, postmortem brain tissue, and mouse and non-human primate model systems.

The Role

We're looking for a Director of Therapeutics Translational Neurobiology to help set scientific strategy, identify novel targets, and lead execution across several therapeutics programs within the Stanley Center's preclinical drug discovery portfolio. This is a leadership role for an experienced drug hunter who has moved beyond running a single project and has prior industry experience shaping larger portfolios. Using insights gained from cutting-edge genetic and neurobiological discoveries at the Stanley Center, this person will help identify new areas for therapeutic discovery investment, develop and execute on these strategic investments, and pursue outside partnerships as projects mature.

The person in this role will report to Morgan Sheng, co-director of the Stanley Center and head of Therapeutics. As a key member of the Stanley Center Therapeutics program, this person will oversee existing projects from target validation to drug discovery and preclinical proof-of-concept and have the independence to form and manage a small team of scientists to identify, develop, and prosecute new targets. This work will be done in close partnership with the larger Stanley Center Therapeutics leadership group and Broad's drug discovery chemistry team (Center for Developing Therapeutics; CDoT). The development of strong relationships with Stanley Center geneticists and neurobiologists will support efforts to drive new target identification. To further advance projects as they mature, and in collaboration with the Broad's Office of Strategic Alliances and Partnerships, this person will build and leverage relationships with biotech and pharma partners to develop external alliances.

Key Responsibilities

Partner with existing Stanley Center therapeutics leadership to define and drive scientific strategy across a portfolio of several therapeutics projects, translating human genetic and biological insights into coherent, prioritized drug discovery plansCollaborate with others in Stanley Center therapeutics leadership on strategic planning and resource allocation across the broader therapeutics programOwn portfolio-level budget planning and managerial oversight across several preclinical therapeutics projects from target validation to drug discovery and preclinical proof-of-conceptOversee and mentor project leads prosecuting on existing targets, while building out a team to develop and drive the prosecution of new targets Foster a strong culture of scientific rigor, collaboration, and professional growth across the teamMake and defend go/no-go and prioritization calls as projects generate new data, balancing scientific rationale, feasibility, and strategic fit with the Center's missionBuild and maintain relationships with biotech and pharma companies, working with the Broad's Business Development office to identify and cultivate partnership opportunities as programs mature toward preclinical proof-of-conceptRepresent the Stanley Center's therapeutics work externally, including in partnering discussions, scientific conferences, and diligence processes

Qualifications

Ph.D. or M.D./Ph.D. in Neuroscience, Pharmacology, Molecular/Cell Biology, Chemistry, or a related life sciences field required10+ years of drug discovery experience in industry (biotech or pharma), with a demonstrated track record of leading programs from target identification through IND-enabling studies or beyond; CNS or psychiatric disease drug discovery experience requiredPrior experience in industry managing a team of scientists, including hiring, mentoring, and performance development; 7+ years' experienceDirect experience managing a multi-project portfolio and making prioritization/resourcing decisions across programsEstablished track record of, or direct exposure to, external partnership development, licensing discussions, or business development in a biotech/pharma or academic drug discovery contextComfort operating in a matrixed organization, balancing scientific direction from principal investigators with programmatic and portfolio ownershipExcellent written and verbal communication skills, with experience presenting to senior leadership, external partners, and scientific audiences

The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.

At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.

The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.

Should you need a reasonable accommodation to complete the application or interview process, please contact [e-mail] for assistance.