Director, Program Management

Alpha-9-Oncology; Boston (MA); On-site; USD 180,000 - 240,000; Full time

Benefits offered by this job

Competitive salary

Bonus

Equity

20 vacation days

5 sick days

Technology allowance

Commuter reimbursement

Retirement plan with employer matching

Job summary

Alpha-9 Oncology seeks a Director of Program Management to drive planning and execution across the radiopharmaceutical pipeline. You will own integrated development plans and coordinate Clinical, Regulatory, CMC, and nonclinical teams to balance quality, speed, and cost.

This hands-on leadership role requires digging into details, raising risks early, and building relationships to keep milestones on track and budgets in check. Strong program management expertise is essential.

Qualifications

• Bachelor's degree in a scientific or related field required.
• Advanced degree (life sciences, MBA, or PMP) preferred.
• 10+ years biotech/pharma experience with 5+ years in drug development program or project management.

Responsibilities

• Partner with program leads to shape priorities and integrated development plans.
• Own and drive execution of integrated plans across Clinical, Regulatory, CMC, and nonclinical teams.
• Develop timelines, identify risks early, and present status and options to leadership.
• Manage program budgets and forecasts with Finance and functional leads.
• Coordinate milestones including IND/CTA filings, study starts, and data readouts.

Job description

Alpha-9 Oncology is seeking a Director, Program Management to join the clinical team to drive planning and execution across our radiopharmaceutical pipeline. Our programs target solid and hematologic malignancies, and with clinical studies now underway, this role brings the structure that keeps programs on time, in scope, and within budget.

Working alongside our program leads and functional experts, you’ll build and own the integrated plans that connect Clinical, Regulatory, CMC, and nonclinical teams. Program strategy and clinical decisions sit with the program leads. Your role is to frame the options, balance quality, speed, and cost, and guide the team to clear decisions, then make sure those decisions are carried through. This is a hands‑on role for someone who digs into the details, raises risks early, and builds trusted relationships across the company to keep work moving.

How You’ll Contribute

• Partner with program leads to shape program priorities and the integrated development plan for assigned programs.
• Serve as program manager for assigned programs, owning the integrated plan and driving execution with Clinical, Regulatory, CMC, and nonclinical teams.
• Build program timelines and scenarios, mapping the dependencies specific to RLT, such as isotope supply, drug product manufacturing, and imaging agent availability.
• Act as the team’s point person on program risk, identifying issues early and driving mitigation and contingency plans with functional leads.
• Present program status, trade-offs, and options to program leads and the leadership team to support timely decisions.
• Coordinate cross‑functional inputs for key milestones, including IND and CTA filings, study starts, and data readouts.
• Run program team meetings, owning agendas, decision logs, and follow‑through on action items.
• Establish the program management tools, templates, and processes that scale with the company.
• Manage program budgets and forecasts in partnership with Finance and functional leads.
• Track deliverables from CROs, CDMOs, and isotope suppliers against the program plan, and escalates when their timelines put milestones at risk.
• Connect nonclinical, CMC, regulatory, and clinical plans as programs move from IND‑enabling work into the clinic.

The Skills You Bring

• Bachelor's degree in a scientific or related field with 10+ years of biotech or pharmaceutical experience, or an advanced degree with 7+ years of experience, including at least 5 years in drug development program or project management.
• Advanced degree in life sciences, MBA, or PMP certification preferred.
• Strong understanding of the drug development lifecycle and the interdependencies across Clinical, Regulatory, CMC, and Nonclinical functions.
• Experience supporting drug development programs through IND or CTA submission and into early‑phase clinical development. Oncology experience preferred.
• Direct experience coordinating cross‑functional activities and inputs for regulatory submissions, key development milestones, and program deliverables.
• Demonstrated ability to develop and maintain integrated program plans, budgets, timelines, and long‑range development strategies.
• Experience identifying and managing program risks, assessing critical path implications, and proactively addressing issues that could affect program timelines or deliverables.
• Ability to influence cross‑functional stakeholders at all levels without direct authority, including CROs and external development partners.
• Strong decision‑making skills, with the ability to frame options, assess trade‑offs, and guide teams toward clear, data‑driven decisions.
• Experience working in both larger pharmaceutical organizations and lean, growing biotech environments, including establishing program management processes and infrastructure from the ground up.
• Proficiency with Smartsheet, Microsoft Project, or similar project management tools.
• Strong communication skills, with the ability to translate complex program activities and status into concise, actionable updates for senior leadership.

What’s in it for you

At Alpha-9 Oncology, we offer a competitive and comprehensive benefits package designed to support all employees.

• competitive salary
• bonus
• equity
• 20 vacation days
• 5 sick days
• a technology allowance
• commuter reimbursement

• generous retirement savings plans with employer matching
• extended health benefits
• paid holidays

tailored to local standards in each region.

Company Summary

Alpha-9 Oncology is a clinical‑stage biotechnology company pioneering radiopharmaceutical innovation for solid tumors. Our proprietary scaffolds, composed of optimized binders, linkers, chelators, and radioisotopes, enable targeted radiation delivery to cancer cells, minimizing harm to surrounding healthy tissue. Focusing on innovative targeting moieties, we develop molecules tailored for precise tumor targeting.

Our comprehensive platform integrates imaging and therapeutic studies to ensure effective radiation delivery and improved patient outcomes. With a robust pipeline entering clinical trials and strong support from leading healthcare investors, Alpha‑9 is positioned for rapid growth and advancement in cancer therapy.

More about Alpha‑9 Oncology

Alpha-9 Oncology is committed to fostering a diverse and inclusive workplace and is proud to be an Equal Opportunity Employer. We provide employment opportunities to all qualified applicants without regard to race, ethnicity, religion, age, sex, gender identity or expression, sexual orientation, disability, marital status, family status, national origin, or any other characteristic protected by applicable federal, provincial, or local laws where we operate.

We are dedicated to providing reasonable accommodations to qualified applicants and employees to ensure that everyone can perform their essential job functions in an inclusive environment. For inquiries regarding accommodations in the hiring process or for current employees, please contact a member from our Talent Acquisition team.

Voluntary Self‑Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Alpha‑9 Oncology’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

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