Senior Director, Clinical Research-Program Executive-Oncology

Vir-Biotechnology; San Francisco (CA); On-site; USD 250,000 - 350,000; Full time

Job summary

Vir Biotechnology is seeking a Senior Director, Clinical Research Oncology Program Executive, located in San Francisco, to lead one or more oncology development programs and serve as the single accountable leader for program strategy, execution, and cross-functional leadership.

The role interfaces with executive leadership to shape direction, prioritize investments, and ensure successful execution of the oncology portfolio.

Qualifications

• MD or PhD with board certification in Oncology, Hematology/Oncology, or related specialty preferred.
• 15+ years of biotech/pharma industry experience with substantial oncology drug development experience.
• Experience leading cross-functional development programs in a matrix environment.
• Demonstrated success guiding oncology development across early and late stages.
• Strong executive communication, facilitation, negotiation, and conflict-resolution skills.

Responsibilities

• Serve as cross-functional leader and single point of accountability for one or more oncology development programs.
• Define and drive overall program vision, clinical development strategy, milestones, and integrated plans.
• Lead cross-functional program teams to align on objectives, timelines, resources, and risk mitigation.
• Partner with executive leadership to support strategic decision-making and portfolio prioritization.
• Ensure programs are resourced and provide oversight on major budget and investment decisions.
• Guide development strategy, trial planning, data interpretation, and key program decisions.

Skills

Executive leadership

Cross-functional leadership

Strategic thinking

Executive communication

Influence and negotiation

Travel readiness

Education

MD or PhD

Board certification in Oncology/Hematology

Job description

Senior Director, Clinical Research-Program Executive-Oncology

Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN ® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies.

Vir Biotechnology has exclusive rights to the universal PRO-XTEN ® masking platform for oncology and infectious disease. PRO-XTEN ® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company.

We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best.

THE OPPORTUNITY

Vir Biotechnology is seeking an experienced Senior Director, Clinical Research Oncology Program Executive (PE) to serve as the development team leader and single point of accountability for one or more oncology development programs. This highly visible leadership role sits at the intersection of clinical development, program strategy, and corporate execution.

The Oncology PE will be responsible for defining and driving the overall development strategy, ensuring alignment across functions, and leading cross-functional teams to achieve key development milestones. The individual will partner closely with executive leadership to shape program direction, evaluate risks and opportunities, prioritize investments, and ensure successful execution of Vir Bio’s oncology portfolio.

You will be successful in this role if you bring deep oncology drug development experience and enjoy translating complex scientific and clinical insights into clear development strategies. You are comfortable working across functions, influencing decisions at all levels of the organization, and helping teams navigate key development milestones and strategic decisions.

This role is located in our San Francisco headquarters with an expectation of at least 3 days per week in office.

WHAT YOU'LL DO

• Serve as the cross-functional leader and single point of accountability for one or more oncology development programs
• Define and drive overall program vision, clinical development strategy, key milestones, and integrated development plans
• Lead cross-functional program teams to align on objectives, priorities, timelines, resource needs, and risk mitigation strategies
• Partner with executive leadership and governance committees to support strategic decision-making and portfolio prioritization
• Ensure programs are appropriately resourced and provide oversight and input on major budget and investment decisions
• Leverage deep oncology and clinical development expertise to guide development strategy, clinical trial planning, data interpretation, and key program decisions
• Represent programs at senior leadership meetings, governance reviews, alliance meetings, regulatory interactions, and other external forums
• Mentor and develop team members while helping strengthen program leadership capabilities across the organization
• Own the integrated development plan and target product profile, including stage gates, evidence requirements, and clear go/no-go recommendations.
• Chair the development team, establish decision rights and accountabilities, resolve issues promptly, and escape material tradeoffs with a recommendation.
• Ensure fit-for-purpose translational medicine, clinical pharmacology, biomarker, companion-diagnostic, and patient-selection strategies from first-in-human development through registration.
• Guide indication prioritization, sequencing, combination strategy, and lifecycle planning based on scientific rationale, unmet need, speed to interpretable data, competitive intensity, regulatory feasibility, and commercial opportunity.
• Define data-readout and evidence-generation plans that support rapid learning, early de-risking, and disciplined investment.
• Partner with Regulatory Affairs on global strategy, health-authority engagement, dose optimization, and expedited-development opportunities supported by data.
• Coordinate Clinical Operations, Biometrics, Safety, CMC/Technical Operations, Medical Affairs, and Commercial to ensure integrated execution, inspection readiness, and a coherent program narrative.
• Maintain integrated financial, timeline, resource, dependency, and risk scenarios; recommend corrective action as assumptions or data change.
• Engage investigators, key opinion leaders, collaborators, and potential partners, incorporating external insights into program strategy.
• Incorporate patient burden, feasibility, diversity, access, and clinically meaningful outcomes into program and study decisions.

WHO YOU ARE AND WHAT YOU BRING

• MD or PhD; board certification in Oncology, Hematology/Oncology, or a related specialty preferred
• 15+ years of biotechnology or pharmaceutical industry experience with substantial experience in oncology drug development
• Demonstrated success leading cross-functional development programs in a matrix environment
• Deep understanding of oncology clinical development, including experience across early and late-stage development
• Experience serving as a Medical Director, Clinical Research Physician, Program Team Leader, or comparable development leadership role
• Strong strategic thinking and ability to integrate scientific, clinical, regulatory, operational, and commercial considerations into development plans
• Exceptional executive communication, facilitation, negotiation, and conflict-resolution skills.
• Experience presenting to executive leadership teams, governance committees, boards, and external stakeholders
• Track record of advancing an oncology program through a major value inflection point, such as first-in-human entry, proof of concept, dose selection, pivotal initiation, regulatory submission, or approval.
• Ability to make decisions under uncertainty and communicate the rationale, assumptions, alternatives, and consequences clearly.
• High integrity, sound judgment, enterprise mindset, and accountability for strategy and execution.
• Ability to travel domestically and internationally as needed.

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Vir Biotechnology’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.