Director, PK Sciences Clinical Pharmacology Artificial Intelligence (AI) Lead

Novartis AG; Cambridge (MA); On-site; USD 186,000 - 345,000; Full time

Benefits offered by this job

Comprehensive benefits package

401(k) with company match

Paid time off

Job summary

Novartis Cambridge, MA seeks a PK Sciences leader to drive AI-enabled strategies for clinical pharmacology across the organization. Lead AI use cases to accelerate PK/PD analyses and dosing recommendations, integrating insights into study design and regulatory documents.

The role requires a Ph.D. or Pharm.D. with 8–10 years in drug development and strong cross-functional leadership, joining a global team in translational medicine at Cambridge.

Qualifications

• Ph.D. or Pharm.D. with clinical pharmacology, DMPK or PK/PD background.
• 8–10 years in drug discovery or development, global teams preferred.
• Experience leading AI strategy and cross-functional project teams.

Responsibilities

• Lead AI strategy for clinical pharmacology within PKS and implement AI use cases.
• Collaborate with Drug Disposition, M&S and clinical teams to inform study design.
• Develop AI-enabled solutions for PK/PD analyses and dosing strategies.
• Prepare regulatory submissions sections and responses with PK input.
• Represent PK Sciences in projects and liaise with regulatory agencies as needed.

Skills

AI strategy

Pharmacokinetics

Cross-functional collaboration

Communication skills

Education

Ph.D./Pharm.D. in clinical pharmacology or PK/PD

Job description

Summary#LI-HybridLocation: Cambridge, Massachusetts, USAThis position is located in Cambridge, Massachusetts, and will not have the ability to be located remotely.We are seeking an enthusiastic and motivated PK Sciences representative to lead the development and use of artificial intelligence (AI) enabled strategies to transform the clinical pharmacology support of transformative new medicines. The successful candidate will offer insight into the development of AI-based applications to support strategic, scientific and operational leadership. They would focus on developing AI-based solutions to enhance the automation, innovation and acceleration of PKS/clinical pharmacology deliverables across the organization. Our unique organizational structure enables colleagues to work seamlessly in the translational and/or clinical space, offering opportunities for development and bench-to-bedside-to-bench translation.Experience in late discovery into clinical development is preferred. The scope of the role potentially includes small molecules, biologics/therapeutic proteins, antibody drug-conjugates, radioligand therapies and/or cell therapies across major therapeutic areas in Novartis, including oncology, immunology, cardiovascular renal metabolism, neuroscience, and global health.This position drives close interdisciplinary collaboration among the PK Science disciplines, Drug Disposition (ADME, BA), Modeling & Simulation (M&S), and Operations through PK science sub-teams to achieve a holistic and integrative perspective of the ADME/clinical pharmacology properties of candidates and drugs. Collaborates effectively with broader, cross disciplinary project teams to ensure PKS strategies are well integrated into project plans and scientific discussions.About the RoleKey ResponsibilitiesLead the development and oversee implementation of AI strategy for clinical pharmacology within PKS.Brings strong AI and digital fluency, using enterprise tools to further strategic, scientific and operational leadership in clinical pharmacologyIdentifies, develops and implements high-value use cases where AI can materially improve clinical pharmacology planning, analyses and decision quality.Represent the PK Sciences function in project teams, interactions with stakeholders within the organization and interactions with regulatory agencies, as appropriateProactively contributes to developing drug candidates across Research Development and Commercial continuum, providing expert pharmacokinetic / drug metabolism and clinical pharmacology inputWork with teams to use AI to accelerate and enhance the understanding of nonclinical and clinical PK/PD relationships and development dosing strategies and predictionsChampion the use of AI to accelerate and enhance the provision of , dosage, and PK/PD components of study protocols, reports, project summaries and development plans, and author pharmacokinetic/clinical pharmacology/biopharmaceutics sections of IND/IMPDs and NDA/BLAs as well as prepare appropriate responses to Health Authority questionsDrives close interdisciplinary collaboration among the PK Science disciplines, Drug Disposition (ADME, BA), Modeling & Simulation (M&S), through PK science sub-teams.Works in close collaboration with clinicians and clinical development colleagues to integrate PKS insights into study design, data interpretation, and project decision‑makingModels the use of Artificial intelligence (AI) / Machine Learning (ML) approaches to enable model guided molecular design, preclinical and clinical data automation, and authoring regulatory documents.This role reports to a Therapeutic Area Unit head within PK Sciences within Translational Medicine (TM) in Biomedical Research. PKS is a global organization situated within Translational Medicine (TM), the clinical research arm of Biomedical Research within Novartis. PK Sciences plays a pivotal role in bringing innovative medicines to patients, by building on research advances to develop new therapies, bridging drug discovery and clinical application. PK Science is an enterprise-wide organization, working across both Biomedical Research and the Development organizations to advance the scientific knowledge of pharmacokinetics, metabolism and clinical pharmacology.Essential RequirementsPh.D. / Pharm.D. with relevant experience in clinical pharmacology, drug metabolism and pharmacokinetics or a related background.A minimum of 8-10 years of experience in drug discovery and/or development in a relevant environment (academia, CRO, biotech or Pharma). 6+ years of experience preferably in a lead role overseeing ADME/DMPK project strategy in translational/clinical development, or in AI strategy.Extensive and in-depth knowledge of pharmacokinetics including, drug metabolism and PK/PD evaluation, experience in working in project teams (preferably global) as well as sound awareness of recent developments in drug development and regulatory sciences.Exposure to working in a cross-functional, matrixed, project-team environment.Strong oral and written communication skills.Desirable RequirementsHands-on project experience with Artificial intelligence (AI) approaches and examples of applying AI to clinical pharmacology topics is a plusLeadership / Novartis Behaviors in ActionDelivers results through disciplined execution, continuous improvement, and a strong focus on value and outcomes.Demonstrates an enterprise mindset and strong ownership by prioritizing resources and decisions for maximum Novartis and patient impact.Role models Novartis leadership behaviors through visible actions, continuous self reflection, and openness to feedbackBuilds trust through transparent communication, clear accountability, and consistent delivery against commitments.Novartis Compensation SummaryThe salary for this position is expected to range between $185,500 and $344,500 per year.The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.U.S.-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time-off package including vacation, personal days, holidays and other leaves.Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-cultureBenefits and Rewards: Learn about all the ways we’ll help you thrive personally and professionally.Read our handbook (PDF 30 MB)EEO Statement:The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.Accessibility & Reasonable AccommodationsThe Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [e-mail] or call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.DivisionBiomedical ResearchBusiness UnitResearchLocationUSAStateMassachusettsSiteCambridge (USA)Company / Legal EntityU175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.Functional AreaResearch & DevelopmentJob TypeFull timeEmployment TypeRegularShift WorkNo