Director - Oligonucleotide Analytical Chemistry

BioSpace; Indianapolis (IN); On-site; USD 148,500 - 257,400; Full time

Job summary

Lilly in Indianapolis, IN is seeking a scientific leader to oversee analytical characterization and development of oligonucleotide, antibody-oligonucleotide, and peptide-oligonucleotide conjugates. The Analytical team partners across sites to build strategic capabilities and ensure capacity, compliance, and efficient processes.

The role requires driving technical strategy, mentoring scientists, and coordinating with cross-functional partners to deliver high-quality data packages for project

Qualifications

• Ph.D. in analytical chemistry, bioanalytical chemistry, or a related field with 7+ years of experience in the biopharmaceutical sector.
• 2+ years of experience in people management and analytical laboratory operations.
• Experience leading analytical efforts in pharmaceutical product discovery and/or development.
• Experience with technical transfer of analytical methods from discovery to development.
• Experience in oligonucleotide analysis and related conjugates.
• Proficient in biophysical and analytical characterization techniques such as MS, chromatography, and light scattering.

Responsibilities

• Provide technical leadership for Lilly Genetic Medicine analytical activities across the organization.
• Partner with Early Phase Development and drug discovery teams to deliver analytical data packages.
• Mentor and develop the scientific team and promote knowledge sharing.
• Plan and manage short-term and long-term analytical investments and timelines.
• Demonstrate learning agility across oligonucleotide modalities and related conjugates.
• Manage collaborations with external and internal analytical vendors.

Skills

People management

Analytical method development

Analytical data packages

Oligonucleotide analysis

Cross-functional collaboration

Strategic planning

Biophysical characterization

Education

Ph.D. in analytical chemistry or related field

Tools

RP chromatography

HILIC

HIC

IEX

SEC

CE

Mass spectrometry

Chromatography

Light scattering

Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

In this role, we are seeking an experienced scientific leader that will have responsibility for ensuring the technical integrity, compliance, and business administration of a Lilly team responsible for analytical characterization and development of oligonucleotides, antibody-oligonucleotide conjugates and peptide-oligonucleotide conjugates. The Analytical team consists of high-level scientists focused on the implementation of new technologies and analytical process improvements. This position involves working cross-functionally within the Indianapolis site and with our site in Boston to develop strategic functional capabilities and ensure appropriate capacity, capabilities and business processes are developed, implemented and sustained to deliver the required information to the project teams. The scientist will be an external leader in this technical area and set the overall strategy for the Lilly Genetic Medicine analytical team across research sites and in cooperation with our cross-functional partners.

Responsibilities

• Provide technical leadership for Lilly Genetic Medicine (LGM) analytical activities to be driven within the organization including analytical characterization, biophysical characterization, downstream processing method development, open-access QC workflows, analytical IT and analytical instrumentation and operation readiness. Ensure methods are technically sound, well developed, and fit-for-purpose.
• Partner with the Early Phase Development team and the drug discovery team to define and deliver appropriate analytical data packages to support molecules advancing from discovery to development
• Mentor and develop scientific team. Ensure continued technical and professional growth of group members, encourage efforts towards excellence and knowledge sharing.
• Plan and manage short-term and long-term analytical investments to support the organization. Develop and/or review technical agendas and timelines for project work. Recommend resource allocation to accomplish projects according to plans, communicate with LGM leadership on progress and propose changes in timeline, objectives, or direction.
• Demonstrate high learning agility and the ability to understand and exploit effective scientific concepts and methods across multiple novel drug modalities, including oligonucleotides, antibody-oligonucleotide conjugates and peptide-oligonucleotide conjugates
• Manage collaborative partnerships with external and internal analytical vendors to supplement LGM analytical resources

Basic Qualifications

• Ph.D. in analytical chemistry, bioanalytical chemistry, or a related field with 7+ years of experience in the biopharmaceutical sector following graduation
• 2+ years of experience in people management and analytical laboratory operations

Additional Skills/Preferences

• Demonstrated expertise leading analytical efforts in pharmaceutical product discovery and/or development with proven skills developing and validating analytical methods
• Experience with technical transfer of analytical methods from discovery to development organizations
• Demonstrated expertise in leading separation sciences for oligonucleotides, including but not limited to RP, HILIC, HIC, IEX, SEC, and CE
• Demonstrated experience in scale-up sample preparation and analytical characterization of oligonucleotides, antibody-oligonucleotide conjugates and/or peptide-oligonucleotide conjugates
• Solid understanding of chemical synthesis, purification and formulation requirements of drug candidate molecules
• Proficiency in biophysical and analytical characterization techniques, including but not limited to light scattering methods, chromatography, mass spectrometry, backgrounded membrane imaging, and other molecular-level characterization tools.

Additional Information

• Travel: 15 to 20%
• Position Location: On-site, Indianapolis, IN; Lilly Corporate Center (LCC)

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$148,500 - $257,400

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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