Director of Manufacturing

Metric Bio; Massachusetts; On-site; USD 180,000 - 260,000; Full time

Job summary

Metric Bio is seeking a Director of Manufacturing for Biologics Drug Product CDMO operations, overseeing sterile manufacturing within a GMP-regulated environment. You will provide strategic leadership across production, drive continuous improvement, and mentor manufacturing teams to meet tight schedules and quality standards.

You will collaborate with Quality, Engineering, and Supply Chain to ensure on-time delivery, process improvements, and successful technology transfers, while upholding

Qualifications

• Significant experience leading manufacturing operations within a pharmaceutical/biotech/CDMO environment.
• Strong background in sterile drug product manufacturing, aseptic processing.
• Proven leadership in GMP-regulated facilities.
• Experience with regulatory compliance and quality systems.
• Ability to drive continuous improvement and cross-functional collaboration.

Responsibilities

• Provide strategic and operational leadership across sterile manufacturing operations, ensuring safe, compliant, and efficient execution of production activities.
• Lead, develop, and mentor manufacturing teams, building a culture of accountability and operational excellence.
• Oversee manufacturing activities to comply with cGMP requirements, regulatory expectations, and internal quality standards.
• Drive improvements across production performance, capacity utilization, right-first-time execution, and manufacturing efficiency.
• Collaborate with Quality, Engineering, Technical Operations, Supply Chain and other stakeholders to ensure reliable production schedules.
• Support technology transfers, process improvements, and introduction of new products or processes.
• Oversee deviation investigations, CAPAs, change controls, and other quality activities in partnership with Quality.
• Contribute to site strategy, resource planning, and development of manufacturing capabilities.

Skills

Sterile manufacturing

GMP operations

Leadership

Regulatory compliance

Cross-functional collaboration

Job description

Title: Director, Manufacturing - Biologics Drug Product CDMO

I'm partnering with a leading global Contract Development and Manufacturing Organisation (CDMO) to appoint a Director of Manufacturing at one of its sterile drug product manufacturing sites.

About the Role

This is a key leadership opportunity for an experienced manufacturing professional to oversee sterile manufacturing operations within a GMP-regulated environment, supporting the delivery of high-quality products for a diverse client portfolio across the biopharmaceutical industry.

Responsibilities

• The successful individual will bring strong technical and operational expertise across sterile drug product manufacturing, alongside a proven ability to lead manufacturing teams, drive operational performance, and maintain the highest standards of quality, safety, and compliance.
• Provide strategic and operational leadership across sterile manufacturing operations, ensuring safe, compliant, and efficient execution of production activities.
• Lead, develop, and mentor manufacturing teams, building a culture of accountability, continuous improvement, and operational excellence.
• Ensure manufacturing activities comply with cGMP requirements, regulatory expectations, and internal quality standards.
• Drive improvements across production performance, capacity utilisation, right-first-time execution, and manufacturing efficiency.
• Collaborate closely with Quality, Engineering, Technical Operations, Supply Chain, and other cross-functional stakeholders to ensure reliable delivery against production schedules.
• Support technology transfers, process improvements, and the introduction of new products or manufacturing processes.
• Oversee deviation investigations, CAPAs, change controls, and other manufacturing-related quality activities in partnership with Quality.
• Contribute to site strategy, resource planning, and the ongoing development of manufacturing capabilities to support business growth and client commitments.

Qualifications

• Significant experience leading manufacturing operations within a pharmaceutical, biotechnology, or CDMO environment.

Required Skills

• Strong background in sterile drug product manufacturing, ideally involving biologics and aseptic processing.
• Proven leadership experience managing manufacturing teams within a GMP-regulated facility.
• Strong understanding of aseptic manufacturing processes, contamination control, and regulatory compliance.
• Track record of improving operational performance, developing teams, and delivering against demanding manufacturing schedules.

Preferred Skills

• Experience working cross-functionally in a client-focused CDMO environment would be advantageous.