Director of IT Infra & Security Ops

Nurix, Inc.; California; On-site; USD 260,000 - 300,000; Full time

Benefits offered by this job

Bonus and equity

Job summary

Nurix Therapeutics, Inc. in Brisbane, CA is seeking a Director of IT Infrastructure & Operations to lead infrastructure, cybersecurity operations, end-user services, and IT service management as one integrated scope.

You will partner with a fractional CISO and collaborate with R&D and scientific computing to align IT with research needs. You will build and manage a hybrid team of staff and MSP partners, set standards, and own IAM, vendor governance, and service experience.

Qualifications

• 12+ years of progressive technology services leadership, including 5+ years at Director level.
• Direct experience leading infrastructure, cyber operations, and ITSM as one integrated scope.
• Proven ability partnering with a CISO on policy while owning execution.
• Experience with AWS plus Entra/Microsoft 365 stack.
• Familiarity with scientific/ML computing infra and DevOps practices.

Responsibilities

• Lead infrastructure, cybersecurity operations, end user services, and ITSM as one integrated scope.
• Consolidate MSPs and vendors, build a governance model with research computing, and align IT with R&D needs.
• Own IAM program and vendor management; refresh service experience end to end.
• Manage a hybrid team of staff and MSPs and set standards for delivery.

Skills

Technology leadership

AWS expertise

Security collaboration with CISO

IT service management

DevOps / IaC

Vendor management

Biotech IT familiarity

Education

Bachelor's degree or equivalent

Tools

AWS ParallelCluster

SageMaker

EKS

ECS

Microsoft Entra

Microsoft 365

Job description

Director, IT Infrastructure & Operations

Brisbane, CA

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

About the role

This is the operating leader for IT infrastructure and operations at Nurix, reporting to the SVP of Information Technology. You will own the function end to end: infrastructure, cybersecurity operations, end user services, and IT service management as one integrated scope. You partner with a fractional CISO on security strategy and policy while owning the operational execution. You work closely with the IT business partner leaders who own the application portfolios and partner directly with R&D and the broader scientific organization on their infrastructure needs.

You lead a team that spans enterprise architecture, system administration, and cybersecurity operations, with the service desk delivered through a mix of staff and managed service providers. You will manage both individual contributors and managers from day one. You set the standards and delegate delivery across this hybrid team of internal staff and managed service providers, empowering the people below you rather than running their queues, to support a fast-moving enterprise.

What you'll do

In your first year you will:

• Consolidate the managed service provider portfolio across infrastructure, security, and the help desk into a smaller, more accountable set of partners.
• Build a cybersecurity operations function from current contractor and MDR coverage.
• Establish a governance model with research and scientific computing, and bring research infrastructure into IT alignment. Working with the enterprise architect, inventory and remediate AWS systems: ParallelCluster and other HPC, container platforms (EKS, ECS), SageMaker, and identity bridges.
• Own a formal identity and access management program, including clean handoffs to IT operations and the business partner teams.
• Refresh the service experience end to end and raise vendor management discipline as scope grows.

Requirements:

• 12+ years of progressive technology services leadership, including 5+ years at the Director or Senior Director level.
• Direct experience leading multi-function technology services (infrastructure, cyber operations, and ITSM) as one integrated scope rather than separate towers.
• Comfort partnering with a CISO or fractional CISO on policy while owning operational execution. We are looking for an operator who builds security in partnership, not someone who pushes controls through operations.
• Deep experience across AWS plus the Microsoft Entra and Microsoft 365 stack.
• Familiarity with the infrastructure behind scientific and ML computing, AWS ParallelCluster and HPC, SageMaker, EKS and ECS, and DevOps and infrastructure-as-code practices, at a level sufficient to set standards and partner credibly with the scientific organization.
• A measurable track record managing a managed service provider portfolio, including real consolidation or vendor transitions with accountability for outcomes.
• Experience building out infrastructure in fast-moving, resource-constrained environments.
• Experience in a regulated industry (biotech, pharma, medical device, healthcare, financial services, or comparable).
• Bachelor's degree or equivalent practical experience.

Nice to have

• Biotech or pharmaceutical industry experience.
• Support for an FDA Pre-Approval Inspection or BIMO inspection in an IT or security capacity.
• Experience standing up a security operations function from contractor or MSP coverage.
• Partnership with a separate scientific computing organization (informatics, bioinformatics, cheminformatics, machine learning).
• Hands-on with an MDR provider such as RedCanary, Kroll, or Arctic Wolf.
• Jira Service Management or ServiceNow at scale.
• Public company SOX IT general controls experience.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Ability to function in a dynamic environment
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Salary Range: $ 260K – $300K plus bonus and equity

Location: Brisbane, CA - Onsite

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy ( https://www.nurixtx.com/privacy-policy/) .

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