Director of Facilities, Laboratory Operations and EHS

Olema; San Francisco (CA); On-site; USD 180,000 - 290,000; Full time

Job summary

Olema Oncology in San Francisco is seeking a strategic Director of Facilities, Laboratory Operations and EHS to lead across multiple sites. You will own day-to-day facility operations, real estate strategy, and lab spaces, with 15% travel to support growth and relocation efforts.

Reporting to the Chief Legal Officer, you will manage capital projects, safety compliance, security programs, and vendor relationships, ensuring continuity of scientific operations while sustaining high standards of

Responsibilities

• Responsible for the day-to-day facility operations, upkeep, and maintenance of a multi-site business
• Lead and execute all facilities operations and physical infrastructure activities across Olema's locations
• Own the execution of Real Estate strategy, including site readiness, lease transitions, expansions, consolidations, and exits
• Lead office and laboratory moves and building relocations, with full accountability for planning, execution, risk management, and stabilization
• Direct laboratory and office buildouts end-to-end, from programming and design through permitting, construction, commissioning, and occupancy
• Execute capital projects in active lab environments while maintaining safety, compliance, and continuity of scientific operations
• Develop and enforce facilities standards, policies, procedures, and SOPs
• Own physical security programs, including access control, badging, alarms, vendor oversight, and incident response
• Control facilities operating and capital budgets, including forecasting, spend management, and cost accountability
• Lead emergency planning and response across all facilities
• Direct shipping and receiving operations, including Hazardous Materials and Dangerous Goods compliance
• Own all workplace services across all locations, including office supplies, beverage and food programs, janitorial services, and waste management, with accountability for vendor performa

Job description

Olema Oncology is a clinical-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. With our transformation into a fully integrated oncology company well underway, it's an exciting time to be part of Team Olema.

Our lead product candidate, palazestrant, is a novel, orally available complete estrogen receptor antagonist (CERAN) and selective estrogen receptor degrader (SERD) currently in two pivotal Phase 3 clinical trials. We expect top-line data from OPERA-01, our ongoing Phase 3 trial of palazestrant as a monotherapy in patients with second- or third-line ER+/HER2- metastatic breast cancer (MBC), in Q1 2027 which, if positive, could lead to our first potential approval and commercial launch in 2028. OPERA-02, our Phase 3 trial of palazestrant in combination with ribociblib in patients with frontline ER+/HER2- MBC, is enrolling patients. Together with its mechanism of action, pharmacokinetic properties, and the potential to demonstrate activity in both ESR1 wild-type and mutant tumors, palazestrant could transform the metastatic breast cancer treatment paradigm and provide access to a $15 billion global market opportunity.

Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with the potential to generate further value and meaningfully impact the metastatic breast cancer treatment landscape - particularly in combination with palazestrant. We recently presented encouraging Phase 1 monotherapy data from this program across multiple solid tumor types, are advancing patient enrollment in the ongoing combination arms in MBC, and expect to initiate a Phase 1 study of OP-3136 in combination with Bayer's darolutamide in metastatic castration-resistant prostate cancer by the end of this year.

Aspiring to transform the metastatic treatment paradigm is an ambitious endeavor that requires a resolute approach to developing better therapies and passionate colleagues dedicated to helping the patients we serve feel better, longer. Team Olema possesses a deep commitment to a shared purpose, the sustained pursuit of excellence, cultivating the courage required to advance our programs, the drive to succeed, and a collective capacity for adaptability through learning, growth, and evolution. We are a small group of nimble self-starters who bring consistency in our quest for the extraordinary every single day.

If you're ready to be part of a tenacious, courageous, agile, and growing team, join us in making a profound impact, together - for our patients, for your career, and for what's beyond.

About the Role >>> Director of Facilities, Laboratory Operations and EHS

As the Director of Facilities, Laboratory Operations and EHS reporting to the Chief Legal Officer, you will be responsible for the strategic leadership, operational excellence, and long-term planning of Olema's facilities and laboratory environments across multiple sites. In this role you will own the full lifecycle of facilities and lab operations, from day-to-day execution to large-scale initiatives including laboratory buildouts, office and lab relocations. The Director, Facilities, Laboratory Operations & EHS will oversee three Olema locations, including BSL2 laboratory environments and corporate office space, and serves as a senior partner to Research, IT, Real Estate, Finance, and Executive Leadership.

This role is based in our San Francisco office and will require 15% travel

Your work will primarily encompass:

Facilities, Real Estate & Capital Execution:

• Responsible for the day-to-day facility operations, upkeep, and maintenance of a multi-site business
• Lead and execute all facilities operations and physical infrastructure activities across Olema's locations
• Own the execution of Real Estate strategy, including site readiness, lease transitions, expansions, consolidations, and exits
• Lead office and laboratory moves and building relocations, with full accountability for planning, execution, risk management, and stabilization
• Direct laboratory and office buildouts end-to-end, from programming and design through permitting, construction, commissioning, and occupancy
• Execute capital projects in active lab environments while maintaining safety, compliance, and continuity of scientific operations
• Develop and enforce facilities standards, policies, procedures, and SOPs
• Own physical security programs, including access control, badging, alarms, vendor oversight, and incident response
• Control facilities operating and capital budgets, including forecasting, spend management, and cost accountability
• Lead emergency planning and response across all facilities
• Direct shipping and receiving operations, including Hazardous Materials and Dangerous Goods compliance
• Own all workplace services across all locations, including office supplies, beverage and food programs, janitorial services, and waste management, with accountability for vendor performa