Director of Analytical Development, AAV Gene Therapy

Rippling, Inc.; Cambridge (MA); On-site; USD 220,000 - 240,000; Full time

Benefits offered by this job

Equity

Annual bonus

Health insurance

Discretionary time off

Job summary

Arbor Biotechnologies, a Cambridge-based clinical-stage gene editing company, seeks a Director, Analytical Development to lead phase-appropriate analytical strategy and method development across AAV programs, ensuring robust control strategies from early development through regulatory submissions.

You will mentor a high-performing team, collaborate with Quality, Regulatory, and external labs, and guide method transfer, validation, and lifecycle management to support GMP readiness and clinical

Qualifications

• Strong leadership in analytical development across multiple development stages.
• Excellent communication and collaboration with QA, Regulatory, and external labs.
• Expertise in developing and transferring analytical methods for viral vectors (AAV).

Responsibilities

• Lead analytical development strategy for AAV-based programs.
• Establish phase-appropriate analytical control strategies for IND-enabling and clinical stages.
• Oversee method transfer, qualification, validation, and comparability testing.
• Support regulatory submissions with analytical sections and data packages.
• Mentor and develop the analytical development team.

Skills

Leadership

Cross-functional collaboration

Analytical method development

Regulatory readiness

Education

PhD in biological sciences or related

MS in related discipline

Job description

Arbor Biotechnologies, a Cambridge-based clinical-stage gene editing company, seeks a Director, Analytical Development to lead phase-appropriate analytical strategy and method development across AAV programs, ensuring robust control strategies from early development through regulatory submissions.

You will mentor a high-performing team, collaborate with Quality, Regulatory, and external labs, and guide method transfer, validation, and lifecycle management to support GMP readiness and clinical