Director, Medical Information

Definium Therapeutics; Durham (NC); On-site; USD 230,000 - 290,000; Full time

Benefits offered by this job

Health insurance

401(k) with company match

Flexible time off

Wellness benefits and perks

Job summary

Definium Therapeutics is seeking a Director of Medical Information to guide the medical information strategy and operations, overseeing external contact center partners. The role requires scientific expertise and leadership to manage vendors, content, and service quality.

The ideal candidate holds an advanced clinical or scientific degree and has extensive experience in medical information operations, including management of outsourced centers, budgets, and service agreements.

Qualifications

• PharmD, PhD, MD or other advanced clinical or scientific degree.
• At least 7 years of pharmaceutical/biotech experience, including 5+ years in Medical Information.
• Experience leading medical information operations and managing outsourced contact centers, vendors, budgets, and service agreements.
• Strong scientific writing, critical literature evaluation, and clinical data interpretation skills.
• Knowledge of scientific exchange, unsolicited off-label inquiries, safety reporting, and privacy; familiarity with medical information systems.

Responsibilities

• Lead Medical Information activities aligned with Medical Affairs priorities, including planning, budgets, and resource oversight.
• Manage medical information contact center vendors, including selection, contracts, service standards, training, quality reviews, and performance.
• Oversee standard response letters, FAQs, and customized responses to unsolicited inquiries for accuracy and nonpromotional content.
• Manage inquiry workflows, content and inquiry systems, procedures, and quality metrics; drive continuous improvement.
• Escalate complex requests and provide scientific guidance to vendors and internal colleagues.
• Coordinate with Pharmacovigilance and Quality on documentation, escalation, and reconciliation of safety reports and product quality complaints; support audits.
• Collaborate with Clinical Development, Medical Affairs, Regulatory, Legal, and Compliance on content review and training.
• Analyze inquiry trends to identify unmet information needs and inform medical strategy.

Skills

Medical information leadership

Cross-functional collaboration

Vendor management

Scientific writing

Education

PharmD/PhD/MD or advanced degree

Tools

Medical information systems

Job description

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.

Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.

Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today's mental health care crisis and enable a healthier future.

Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.

Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!

The Director, Medical Information will lead the medical information strategy and operations, including oversight of external contact center partners. This role ensures accurate, balanced, and timely scientific responses to healthcare professionals, patients, and caregivers. The ideal candidate combines scientific expertise with operational leadership and a collaborative approach to managing vendors, content, and service quality.

Responsibilities

• Lead Medical Information activities aligned with Medical Affairs priorities, including departmental planning, budgets, and oversight of internal and external resources
• Manage medical information contact center vendors, including selection, contracts, service standards, training, quality reviews, and performance
• Oversee standard response letters, FAQs, and customized responses to unsolicited inquiries, ensuring scientific accuracy, appropriate balance, and nonpromotional content
• Manage inquiry workflows, content and inquiry systems, operating procedures, and quality metrics; drive continuous improvement
• Serve as the escalation point for complex requests and provide scientific guidance to vendors and internal colleagues
• Partner with Pharmacovigilance and Quality on documentation, escalation, and reconciliation of safety reports and product quality complaints; support audit readiness
• Collaborate with Clinical Development, Medical Affairs, Regulatory, Legal, and Compliance on content review, scientific training, and appropriate information exchange
• Analyze inquiry trends to identify unmet information needs and share insights that inform medical strategy and educational resources

Qualifications

• PharmD, PhD, MD, or another relevant advanced clinical or scientific degree
• At least 7 years of pharmaceutical or biotechnology experience, including at least 5 years in Medical Information
• Experience leading medical information operations and managing outsourced contact centers, vendors, budgets, and service agreements
• Strong scientific writing, critical literature evaluation, and clinical data interpretation skills
• Knowledge of requirements for scientific exchange, unsolicited off-label inquiries, safety reporting, and privacy; experience with medical information systems
• Ability to lead across functions, manage competing priorities, and contribute directly to scientific and operational work
• Psychiatry or neuroscience experience preferred

Individual compensation within the range is determined based on factors such as relevant skills, experience, qualifications, scope of the role, and other legitimate business considerations. In addition to base salary, this role may be eligible for bonus and equity opportunities. We also offer a comprehensive benefits package including health insurance, 401(k) with company match, flexible time off and additional wellness benefits and perks. Learn more about our benefits on our Careers page.

The anticipated base salary range for this position is:

$230,000—$290,000 USD