Director, Global Drug Substance Commercialization, Polysaccharide

Vaxcyte; San Carlos (CA); Hybrid; USD 208,000 - 242,000; Full time

Job summary

An innovative clinical-stage vaccine company seeks a Director of Global Drug Substance Commercialization. This pivotal role focuses on leading launch readiness and supply chain activities for polysaccharides in glycoconjugate vaccines. The ideal candidate will have extensive experience in biologic production processes, particularly with bacterial fermentation and purification. You will drive strategic leadership, ensuring process robustness and effective communication with stakeholders. Join a forward-thinking organization committed to excellence and innovation in combating serious bacterial diseases, where your contributions will significantly impact public health.

Qualifications

• 10+ years of experience in relevant fields for Ph.D. candidates.
• Extensive experience with polysaccharides and glycoconjugate vaccines.

Responsibilities

• Lead launch readiness and supply chain activities for polysaccharides.
• Provide strategic leadership and build a skilled team.

Skills

Biologic production processes

Bacterial fermentation

Problem-solving skills

Leadership experience

Data-driven decision-making

Education

Ph.D. in Chemical or Biochemical Engineering

M.S. in relevant field

B.S. in relevant field

Job description

Director, Global Drug Substance Commercialization, Polysaccharide

Join to apply for the Director, Global Drug Substance Commercialization, Polysaccharide role at Vaxcyte.

Vaxcyte is a clinical-stage vaccine innovation company dedicated to engineering high-fidelity vaccines to combat bacterial diseases with serious health consequences. Our focus includes eradicating or treating infections such as invasive pneumococcal disease, Group A Strep, periodontitis, and Shigella. We are committed to innovation and excellence, guided by core values such as rethinking convention, aiming high, leading with heart, and modeling excellence.

The Director of Drug Substance (DS) Commercialization for Polysaccharides will lead launch readiness and supply chain activities for polysaccharides used in glycoconjugate vaccines. Responsibilities include technical launch planning, cross-functional coordination, regulatory filings, and lifecycle management. The role reports to the Executive Director for Global DS Commercialization and involves collaboration on overall program strategy, focusing on raw material strategy.

Key functions include providing strategic leadership, building and leading a skilled team, ensuring process robustness, facilitating technology transfer, supporting manufacturing and regulatory activities, and effective communication with stakeholders. Travel requirements are approximately 10-30%.

Minimum requirements:

• Degree in Chemical or Biochemical Engineering, Chemistry, Biochemistry, or related field with extensive relevant experience (10+ years for Ph.D., 12+ for M.S., 16+ for B.S.).
• Extensive experience in biologic production processes, especially with bacterial fermentation, recovery, and purification; experience with polysaccharides and glycoconjugate vaccines preferred.
• Leadership experience in MSAT or Process Development, with supervisory or matrixed roles.
• Strong technical, organizational, problem-solving, and communication skills.
• Proactive, data-driven decision-making ability, entrepreneurial mindset.

This position is based in San Carlos or remote, with a competitive salary range of $208,000 - $242,000 plus benefits and equity. We are an equal opportunity employer.