Director, Epidemiology & Methodological Innovation

Tempus, Inc.; Chicago (IL); On-site; USD 170,000 - 230,000; Full time

Benefits offered by this job

Incentive compensation

Restricted stock units

Medical benefits

Job summary

Tempus, Inc. is seeking a Director of Epidemiology & Methodological Innovation to lead high-impact research for biopharma partners. This role involves developing novel methodologies for real-world evidence and overseeing research projects that bridge data science and biostatistics. Candidates should have at least 7 years in health economics and a strong oncology background. Located in Chicago, the position offers a competitive salary range from $170,000 to $230,000 with comprehensive benefits.

Qualifications

• 7+ years in HEOR/RWE with leadership experience.
• Deep expertise in oncology required.
• Proven track record in advanced methods.

Responsibilities

• Lead the development of novel approaches for RWE.
• Oversee the execution of retrospective database analyses.
• Serve as a subject matter expert for biopharma clients.

Skills

Epidemiology

Biostatistics

Health Economics

Client Strategy

Data Science

Education

PhD or PharmD in Epidemiology or related field

Tools

R

SAS

Job description

Director, Epidemiology & Methodological Innovation page is loaded## Director, Epidemiology & Methodological Innovationlocations: Chicagotime type: Full timeposted on: Posted Todayjob requisition id: JR202600382Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.**The Director of Epidemiology & Methodological Innovation will lead high-impact research for Tempus’s biopharma partners, sitting at the intersection of traditional outcomes research and cutting-edge data science. This is a high-visibility, client-facing role within the Data Business. You won’t just apply existing frameworks; you will develop and validate novel epidemiological methods to unlock the full potential of Tempus’s multimodal datasets. The ideal candidate is a scientific visionary who can translate complex, non-linear data into regulatory-grade insights that accelerate drug development and improve patient outcomes.****Key Responsibilities*** **Methodological Innovation: Lead the development of novel approaches for RWE, including the use of external control arms (ECA), causal inference in high-dimensional data, and the integration of longitudinal clinical data with molecular/genomic signatures.*** **Research Design & Implementation: Oversee the end-to-end execution of retrospective database analyses. You will act as the primary architect for study protocols, ensuring they push the boundaries of current HEOR/RWE standards while maintaining scientific rigor.*** **Scientific Thought Leadership: Serve as a subject matter expert for biopharma clients, advising them on "first-in-kind" study designs. You are expected to contribute to the broader scientific community through high-impact publications and presentations at conferences like ISPOR, ICPE, and ASCO.*** **Client Strategy & Partnership: Partner with Key Account Directors and Business Development to identify opportunities where novel methodology can solve "unsolvable" client problems (e.g., rare disease characterization or complex biomarker validation).*** **Cross-Functional Synergy: Bridge the gap between Data Science, Biostatistics, and Product teams to productize successful novel methods, ensuring they are scalable across the Tempus ecosystem.*** **Project Management & Quality: Ensure all innovative research meets stringent regulatory and ethical standards (e.g., GEP, HIPAA), delivering high-quality results on timelines that match the pace of the biopharma industry.****Qualifications*** **Education: PhD (preferred) or PharmD in Epidemiology, Biostatistics, Health Economics, or a related quantitative field.*** **Experience: 7+ years in HEOR/RWE, with at least 3 years in a leadership capacity.*** **Deep expertise in oncology is required.*** **Methodological Mastery: Proven track record of developing or implementing advanced methods (e.g., target trial emulation, propensity score applications in complex cohorts, or machine learning-augmented epidemiology).*** **Technical Proficiency: Advanced skills in R or SAS. Experience working with "messy" real-world data (EHR, claims, and/or genomic data) is essential.*** **The "Consultant" Mindset: Exceptional ability to walk into a room of biopharma executives and simplify complex methodological hurdles into a clear strategic roadmap.*** **Leadership: Demonstrated experience mentoring junior scientists and leading cross-functional squads in a fast-paced, high-growth environment.**CHI: $170,000-$230,000NYC/SF: $180,000-$250,000The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.We’re looking for people who can change the world.Who question the status quo and don’t shy away from tough problems. For the builders who are never done building and the learners who are never done learning. We’re looking for passionate people with undying curiosity. Those who want to attack one of the most challenging problems mankind has ever faced. Head on.