Director, DMPK (or Senior Director)

BioAge; Northern (KY); Hybrid; USD 230,000 - 290,000; Full time

Benefits offered by this job

Remote work

Health and wellness benefits

401(k) with match

Paid time off

Job summary

BioAge Labs is seeking an experienced Director, DMPK (or Senior Director) to lead DMPK and translational pharmacology across the portfolio. This fully remote role welcomes candidates from any continental US state, reporting to the VP of Non Clinical Development.

You will drive ADME, PK/PD modeling, and dose selection for IND-enabling programs. Responsibilities include partnering across disciplines, guiding regulatory submissions, and mentoring scientists while advancing BioAge's mission in aging

Qualifications

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Drug Metabolism, or related field.
• 12+ years in biotech/pharma with small molecule development experience.
• Led DMPK strategy across multiple programs and IND-enabling work.
• Experience supporting regulatory submissions (INDs/CTAs).
• Experience coordinating with external CROs and collaborators.
• Proven leadership in cross-functional teams.

Responsibilities

• Lead DMPK and translational pharmacology across BioAge pipelines from lead optimization to IND-enabling studies.
• Develop ADME, PK/PD, and dose selection strategies; optimize human dose prediction.
• Design and oversee in vitro/in vivo DMPK, metabolite ID, and bioanalytical studies.
• Partner with chemistry, biology, toxicology, and clinical pharmacology to guide programs.
• Direct quantitative PK/PD and PBPK modeling to inform decisions.
• Mentor scientific staff and build decision-making frameworks for translational science.

Skills

DMPK

ADME

PK/PD

Regulatory submissions

CRO management

Team leadership

Pharmacology

Bioanalysis

Data interpretation

Regulatory strategy

Education

PhD in Pharmacokinetics/Pharmaceutical Sciences

Tools

PBPK modeling

Population PK

Job description

BioAge Labs (BIOA) is finding new ways to treat disease by targeting the mechanisms of aging, with the ultimate goal of increasing healthy human lifespan. https://bioagelabs.com

We are seeking an experienced Director, DMPK (or Senior Director) . This is a fully remote position, and the successful candidate can live in any of the continental US states.

Position Summary

Reporting to the VP, Non Clinical Development, the Director, DMPK will lead the company's DMPK and translational pharmacology function, collaborating across disciplines to optimize candidate selection, clinical translation, and regulatory success.

Job Duties

• Lead the Drug Metabolism and Pharmacokinetics (DMPK) and translational pharmacology strategy across BioAge's pipeline, supporting programs from lead optimization through IND-enabling studies and clinical development.
• Develop integrated DMPK and translational pharmacology strategies to optimize absorption, distribution, metabolism, excretion (ADME), exposure, tissue distribution, pharmacokinetic/pharmacodynamic (PK/PD) relationships, and human dose prediction.
• Design, oversee, and interpret in vitro and in vivo DMPK, ADME, metabolite identification, and bioanalytical studies to enable informed candidate selection and progression decisions.
• Partner closely with Medicinal Chemistry, Discovery Biology, Biomarkers, Toxicology, Clinical Pharmacology, and Clinical Development to integrate DMPK data into overall program strategy and decision-making.
• Design, direct, and interpret quantitative PK/PD, exposure-response, and PBPK/population-PK modeling that integrates nonclinical and clinical data, driving mechanism-based dose selection and model-informed drug development .
• Provide scientific leadership for first-in-human dose projections, clinical pharmacology strategy, and translational plans that bridge preclinical findings to clinical development.
• Identify and proactively address DMPK risks and optimization opportunities, including drug-drug interaction potential, metabolite characterization, formulation considerations, and species translation.
• Select, manage, and oversee external CROs and strategic partners conducting DMPK, bioanalytical, and translational pharmacology studies, ensuring high scientific quality, timely execution, and regulatory compliance.
• Author and review DMPK and clinical pharmacology sections of regulatory submissions, including INDs, CTAs, Investigator's Brochures, and related documentation, and support interactions with global regulatory authorities.
• Build and continuously improve DMPK capabilities, scientific standards, and decision-making frameworks, evaluating and adopting emerging approaches in quantitative pharmacology and translational science to strengthen BioAge's platform.
• Communicate DMPK strategy, data, and recommendations to cross-functional teams, leadership, and external partners to drive key development and portfolio decisions.
• Mentor and develop internal scientific talent while fostering a collaborative, innovative, and data-driven culture across cross-functional teams.

Required Education & Experience

• Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Drug Metabolism, or a related scientific discipline.
• 12+ years of relevant biotechnology and/or pharmaceutical industry experience following completion of a Ph.D., with demonstrated success advancing small molecule therapeutics from discovery through early clinical development.
• Proven experience leading DMPK strategy for multiple drug discovery and development programs, including candidate selection, IND-enabling studies, and first-in-human dose projection.
• Demonstrated experience supporting regulatory submissions, including authorship or review of DMPK and clinical pharmacology sections of INDs, CTAs, Investigator's Brochures, and related regulatory documents.
• Experience serving as the DMPK representative on multidisciplinary program teams and influencing key portfolio and development decisions.
• Experience selecting, managing, and overseeing external CROs and scientific collaborators.
• Experience mentoring scientists and providing technical leadership within cross-functional organizations.

Required Qualifications

• Deep expertise in drug metabolism and pharmacokinetics (DMPK), ADME, bioanalysis, metabolite identification, and disposition of small molecule therapeutics.
• Strong understanding of translational pharmacology, pharmacokinetic/pharmacodynamic (PK/PD) relationships, exposure-response analyses, and quantitative approaches to dose selection.
• Demonstrated ability to integrate DMPK, pharmacology, biomarker, and toxicology data to inform candidate optimization and development strategy.
• Working knowledge of regulatory expectations for DMPK and clinical pharmacology, including FDA, EMA, and ICH guidance.
• Strong scientific judgment with the ability to evaluate complex data, identify development risks, and recommend practical solutions.
• Excellent written and verbal communication skills, including experience presenting to executive leadership and authoring high-quality scientific and regulatory documents.
• Proven ability to thrive in a collaborative, fast-paced, remote biotechnology environment while effectively managing multiple priorities.

Preferred Qualifications

• Experience with quantitative pharmacology approaches, including physiologically based pharmacokinetic (PBPK) modeling and/or population pharmacokinetic analyses.
• Experience in age-related diseases, metabolic disease, obesity, cardiometabolic disease, or other chronic disease therapeutic areas.
• Experience building DMPK capabilities and scientific strategy within a growing biotechnology company.
• Prior direct people management experience is a plus

Our company

BioAge is a clinical-stage biopharmaceutical company harnessing the biology of human aging to develop new therapies for metabolic diseases. The Company’s human-first discovery platform analyzes proprietary multi-omics data captured over decades to identify molecular pathways that drive metabolic aging and disease. BioAge’s lead program, BGE-102, is a potent, orally available, brain-penetrant NLRP3 inhibitor being developed for diseases driven by inflammation. The Company is also advancing oral and injectable APJ agonists—exercise mimetics with the potential to enhance incretin-driven weight loss and restore healthy body composition in obesity. BioAge’s discovery platform is validated by ongoing research collaborations with Novartis and Lilly. BioAge has been listed on Nasdaq (BIOA) since 2024. For additional information about BioAge, visit the company’s website at https://bioagelabs.com.

BioAge offers competitive salary, a comprehensive compensation package, and generous paid time off in addition to company-observed holidays. We provide comprehensive health and wellness benefits (medical, dental, and vision insurance) and a 401(k) retirement savings plan with matching employer contributions, and we support families through childcare and fertility benefits. We also pride ourselves in giving employees many opportunities for career development, including a generous annual budget for continued learning and a dedication to training and skill development. Many positions (including this one) are remote, allowing our team members to work from anywhere. The salary for this role is expected to be approximately $230,000 - $290,000, depending on experience. We are open to the concept that different experience levels add value to the team in different ways, and therefore will consider a variety of experience and offer commensurate pay.

At BioAge, we embrace diversity and differences while we learn from each other, and we believe that every team member has an important role to play. We are an equal opportunity employer. BioAge prohibits discrimination and harassment of any type and affords equal employment opportunities to employees and applicants without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law. BioAge conforms to the spirit as well as to the letter of all applicable laws and regulations.