Director, Data Management

Enigma Search; South San Francisco (CA); On-site; USD 180,000 - 230,000; Full time

Job summary

Maze Therapeutics is seeking a Director of Data Management to lead clinical data management strategy and execution across multiple development programs. This role reports to the VP of Biometrics and partners with Biostatistics, Regulatory Affairs, Clinical Operations, and external vendors to ensure high-quality, analysis-ready data for regulatory submissions and business decisions.

The position combines strategic leadership with operational oversight, overseeing DMPs, CRFs/eCRFs, edit checks,

Qualifications

• Bachelor's degree in Life Sciences, Computer Science, or a related field; advanced degree preferred.
• 8+ years of clinical data management experience within biotech, pharmaceutical, or CRO settings.
• 3+ years of leadership experience managing people, projects, or both.
• Experience with EDC platforms such as Medidata Rave or Oracle InForm.
• Strong knowledge of clinical trial operations, data management processes, and regulatory requirements.
• Proven ability to work cross-functionally, influence stakeholders, and lead through collaboration.
• Strong mentoring, communication, and organizational skills.

Responsibilities

• Lead clinical data management activities across multiple studies and development phases.
• Develop and implement data management strategies, standards, and best practices.
• Serve as the subject matter expert for data management processes, systems, and regulatory requirements.
• Oversee key deliverables, including DMPs, CRFs/eCRFs, edit checks, data review, reconciliation activities, and database locks.
• Ensure timely, accurate, and consistent clinical data collection and cleaning.
• Review and approve study documentation and ensure readiness for analysis and reporting.
• Partner with Biostatistics, Medical Writing, and Clinical Operations to support study execution and reporting.
• Manage CROs and external vendors to ensure quality, timelines, and deliverables are met.
• Support the evaluation and optimization of EDC systems and related technologies.
• Provide strategic input into protocol design, operational planning, and risk mitigation.
• Mentor and develop data management team members while promoting collaboration and knowledge sharing.

Skills

Leadership

Cross-functional collaboration

Mentoring

Communication

Organizational skills

Education

Bachelor's degree in Life Sciences

Advanced degree preferred

Tools

Medidata Rave

Oracle InForm

Job description

Maze Therapeutics is seeking a Director of Data Management to lead clinical data management strategy and execution across multiple development programs. Reporting to the Vice President of Biometrics, you will partner with Biostatistics, Statistical Programming, Clinical Operations, Regulatory Affairs, and external vendors to ensure the delivery of high-quality, compliant, and analysis-ready clinical data.

This role combines strategic leadership with operational oversight and will play a critical part in supporting clinical development, regulatory submissions, and key business decisions.

Key Responsibilities

• Lead clinical data management activities across multiple studies and development phases.
• Develop and implement data management strategies, standards, and best practices.
• Serve as the subject matter expert for data management processes, systems, and regulatory requirements.
• Oversee key deliverables, including DMPs, CRFs/eCRFs, edit checks, data review, reconciliation activities, and database locks.
• Ensure timely, accurate, and consistent clinical data collection and cleaning.
• Review and approve study documentation and ensure readiness for analysis and reporting.
• Partner with Biostatistics, Medical Writing, and Clinical Operations to support study execution and reporting.
• Manage CROs and external vendors to ensure quality, timelines, and deliverables are met.
• Support the evaluation and optimization of EDC systems and related technologies.
• Provide strategic input into protocol design, operational planning, and risk mitigation.
• Mentor and develop data management team members while promoting collaboration and knowledge sharing.

Qualifications

• Bachelor's degree in Life Sciences, Computer Science, or a related field; advanced degree preferred.
• 8+ years of clinical data management experience within biotech, pharmaceutical, or CRO settings.
• 3+ years of leadership experience managing people, projects, or both.
• Experience with EDC platforms such as Medidata Rave or Oracle InForm.
• Strong knowledge of clinical trial operations, data management processes, and regulatory requirements.
• Proven ability to work cross-functionally, influence stakeholders, and lead through collaboration.
• Strong mentoring, communication, and organizational skills.