Director, Computational Biology

Initial Therapeutics, Inc.; South San Francisco (CA); On-site; USD 225,000 - 275,000; Full time

Job summary

An established industry player is seeking a Director of Computational Biology to transform genetic insights into innovative therapies. This pivotal role involves leading a talented team, driving strategic initiatives, and leveraging cutting-edge bioinformatics to enhance drug discovery processes. You will collaborate across various scientific disciplines, ensuring that your contributions significantly impact therapeutic programs. With a focus on multi-omics data analysis and strategic partnerships, this position offers the opportunity to shape the future of medicine while working in a dynamic and supportive environment that values creativity and teamwork. Join a passionate team dedicated to making a difference in patients' lives through advanced science.

Benefits

Medical Insurance

Dental Insurance

Vision Insurance

Mental Health Offerings

Equity Incentive Plan

401(k) Program with Employer Match

Generous Holiday and PTO Policy

Qualifications

• PhD in Computational Biology or related field with 8+ years experience.
• Expertise in analyzing data from various genomics technologies.

Responsibilities

• Lead the development of strategies for analyzing multi-omics datasets.
• Build and lead a team of computational biologists.

Skills

Computational Biology

Data Analysis

Cross-Functional Collaboration

Leadership

Genomics Technologies

Artificial Intelligence

Communication Skills

Education

PhD in Computational Biology

Tools

Bioinformatics Platforms

Job description

The Position

The Translational Genomics team at Maze Therapeutics is seeking an innovative Director of Computational Biology to play a pivotal role in transforming genetic insights into life-changing therapies. You will lead the development and implementation of strategies to analyze internal and external multi-omics datasets using proprietary computational pipelines. Your work will be central to target validation and understanding how drugs impact biological pathways, helping to shape the future of drug discovery at Maze.

As a key member of our Translational Genomics team, you will collaborate across human genetics, functional genomics, data science, biology, and drug discovery groups. You will also build and lead a team of computational biologists to drive innovation and maximize the impact of our therapeutic programs. This position reports to the VP of Translational Genomics and will require you to provide strategic insights and updates to leadership on the progress and outcomes of ongoing projects.

The Impact You’ll Have

1. Lead Innovation: Drive Maze's strategy in scientific and technological advancements through the implementation of cutting-edge bioinformatics platforms to accelerate our understanding of biological pathways and genetic effects on human disease.
2. Data Analysis: Perform and oversee comprehensive analyses of internal and external multi-omics datasets to accelerate the evaluation and development of therapeutic programs.
3. Cross-Functional Collaboration: Partner with Genetics, Functional Genomics, Data Science, and Biology teams to design experiments and seamlessly integrate computational and experimental data.
4. Strategic Partnerships: Identify and foster collaborations with contract research organizations and academic institutions to leverage the latest advancements in the multi-omics field.
5. Pipeline Development: Design, implement, and execute robust computational pipelines to address complex biological challenges, such as characterizing the molecular impact of disease-associated genetic variants.

As a Director, we also expect our leaders to demonstrate the following Leadership Competencies:

1. Communication and Influence
   • Builds communication channels across Maze for sharing information
   • Influences Senior Management decisions through persuasive arguments
   • Respectfully addresses differing opinions leading to support of decision
2. Teamwork and Collaboration
   • Champions partnerships and connections across Maze
   • Proactively addresses issues that could result in breakdown of team relationships
   • Spotlights team and individual contributions in public forums
3. Execution and Results
   • Addresses gaps and leverages strengths to get best results
   • Maintains a steadying presence and clarifies priorities during change
   • Anticipates and removes barriers that put functional/corporate goals at risk
4. Develop Others and Self
   • Removes barriers to staff development and empowers them to make their own decisions
   • Stays current on industry trends and keeps direct-reports prepared and responsive

What We’re Looking For

1. PhD in Computational Biology, Human Genetics, Bioinformatics or related field, with 8+ years of experience in a computational biology or drug development role, ideally in industry.
2. 3+ years of experience building and leading high-performing teams of Scientists and/or Engineers.
3. Expertise analyzing and interpreting data from a variety of genomics technologies including RNA-seq, single cell technologies, spatial transcriptomics, long read RNA-seq, and CUT&RUN.
4. Track record of successfully integrating generative Artificial Intelligence into computational biology workflows.
5. Demonstrated experience driving impactful contributions to early- and late-stage research programs, including refining computational workflows, and implementing innovative technologies to accelerate drug discovery efforts.
6. A recognized leader in the field, demonstrated through patents, academic publications, or contributions to regulatory bodies.
7. Experience integrating human genetics and multi-dimensional data to prioritize drug targets.
8. Exceptional communication and cross-functional leadership skills with a strong record of collaboration with interdisciplinary teams.

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. We are advancing a pipeline using our Compass platform, which allows us to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process we refer to as variant functionalization. Our Compass platform has been purpose-built to inform all phases of our drug discovery and development process through clinical trial design. We are currently advancing two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease, or CKD. Our goal is to bring novel precision medicines to patients with common diseases, which is where we believe we can maximize our impact on human health.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $225,000 - $275,000. Additionally, this position is eligible for an annual performance bonus. Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.