Director, Clinical Sciences

Tango Therapeutics, Inc; Boston (MA); On-site; USD 190,000 - 286,000; Full time

Job summary

Tango Therapeutics, Inc is seeking a Director, Clinical Sciences to lead scientific contributions across clinical programs and to drive robust study design, execution, and interpretation of oncology trials.

You will collaborate with Clinical Development, Biostatistics, Regulatory Affairs and Medical Writing to ensure high-quality clinical program outcomes and regulatory readiness. This hands-on role requires significant prior leadership in clinical science and oncology settings.

Qualifications

• MD/PhD/PharmD/MS in a relevant scientific discipline.
• 10+ years of experience in clinical science or research.
• At least 5 years of experience in oncology.
• Strong analytical skills with statistical analysis and interpretation of clinical data.
• Excellent written and oral communication skills, with the ability to convey complex scientific concepts to diverse audiences.
• Experience working in a fast-paced environment.

Responsibilities

• Scientific contribution to one or more clinical programs to ensure the design, execution, and interpretation of clinical studies.
• Provide scientific leadership throughout design, execution, analysis, and interpretation of early- and late-stage oncology clinical trials.
• Partner with Clinical Development physicians, Clinical Operations, Biostatistics, Clinical Pharmacology, Pharmacovigilance, Regulatory Affairs, Translational Medicine, and Medical Writing to ensure high-quality execution of clinical programs.
• Contribute to development and review of key clinical documents, including protocols, investigator brochures, informed consent forms, clinical study reports, clinical development plans, and regulatory briefing materials.
• Interpret emerging clinical, safety, PK/PD, and biomarker data to inform study conduct, dose selection, expansion opportunities, and overall development strategy.
• Contribute scientific expertise to regulatory submissions and health authority interactions.
• Foster a collaborative, accountable, and scientifically rigorous culture within the Clinical Science function.
• Perform additional duties and responsibilities as required.

Skills

Clinical science experience

Oncology experience

Statistical analysis

Communication skills

Fast-paced environment

Education

MD/PhD/PharmD/MS in a relevant scientific discipline

Job description

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

Tango is located at 201 Brookline Avenue, in the vibrant Fenway area of Boston, Massachusetts.

Summary

Tango has an exciting opportunity to join the team as our Director, Clinical Sciences. This is a hands‑on role with scientific contributions to one or more clinical development programs. The successful candidate will actively engage in the design, execution, analysis, and interpretation of clinical studies. You will ensure scientific rigor throughout study conduct, lead data review and analysis, and partner cross‑functionally to advance clinical development programs. This role reports to the Executive Director, Clinical Sciences.

Your Role:

• Scientific contribution to one or more clinical programs to ensure the successful design, execution, and interpretation of clinical studies
• Provide scientific leadership throughout the design, execution, analysis, and interpretation of early- and late-stage oncology clinical trials
• Partner closely with Clinical Development physicians, Clinical Operations, Biostatistics, Clinical Pharmacology, Pharmacovigilance, Regulatory Affairs, Translational Medicine, and Medical Writing to ensure high-quality execution of clinical programs
• Contribute to the development and review of key clinical documents, including protocols, investigator brochures, informed consent forms, clinical study reports, clinical development plans, and regulatory briefing materials
• Interpret emerging clinical, safety, PK/PD, and biomarker data to inform study conduct, dose selection, expansion opportunities, and overall development strategy
• Contribute scientific expertise to regulatory submissions and health authority interactions
• Foster a collaborative, accountable, and scientifically rigorous culture within the Clinical Science function
• Perform additional duties and responsibilities as required

What You Bring:

• MD, PhD, PharmD, MS within a relevant scientific discipline
• At least 10 years of experience in clinical science, or research
• At least 5 years of experience in oncology
• Demonstrated experience in designing and managing clinical trials, including knowledge of regulatory guidelines and GCP
• Strong analytical skills with proficiency in statistical analysis and interpretation of clinical data
• Excellent written and oral communication skills, with the ability to convey complex scientific concepts to diverse audiences
• Experience working in a fast‑paced environment

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range

$190,400 - $285,600 USD

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Tango Therapeutics’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.