Director, Clinical Research- Benign Hematology

Alnylam Pharmaceuticals, Inc.; Philadelphia (Philadelphia County); Presencial; USD 255.000 - 345.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Medical, dental & vision

Life and disability insurance

401(k) with company match

Paid time off & holidays

Wellness days & recharge breaks

Descripción de la vacante

Alnylam Pharmaceuticals, Inc. is seeking an imaginative physician drug developer to provide clinical leadership across neurology and hematology.

The Director, Clinical Research will lead plasminogen program development from Phase 2 to Phase 3 and drive global regulatory interactions in a matrix organization. The role requires strategic direction, collaboration with Regulatory, Biostatistics, and Medical Affairs, and accountability for study timelines and deliverables; strong leadership and

Formación

• MD with strong research background or MDPhD with best clinical and/or research training as shown through research support and peer‑reviewed publications.
• Board Certification in hematology desirable.
• 3+ years industry experience or equivalent clinical academic research experience.
• Familiarity with biostatistics and regulatory agency practices.
• Ability to present ideas and document complex medical concepts clearly.
• Leadership and collaboration in a matrix environment.

Responsabilidades

• Be a subject matter expert for the relevant disease area(s).
• Be the strategic leader providing a strong voice for the clinical program.
• Develop creative but realistic drug development approaches and lead clinical efforts toward global regulatory approvals.
• Oversee trial conduct and safety.
• Collaborate with Preclinical, Regulatory Affairs and Medical Affairs for integrated product development plans.
• Accountable for timelines and deliverables in Clinical Research and Operations.
• Supervise major regulatory submissions, articles, abstracts, and presentations.
• Review and sign off on protocols, investigator brochures and informed consent forms.

Conocimientos

MD/MDPhD

Board Certification

Clinical research experience

Leadership in matrix teams

Educación

MD/MDPhD

Descripción del empleo

Overview

Alnylam Pharmaceuticals is seeking an imaginative physician drug developer, with the flexibility and confidence to work across diseases within the neurology and hematology therapeutic area. This role includes the opportunity to provide clinical leadership in developing RNAi therapeutics in Alnylam’s expanding portfolio, which spans from rare genetic to common diseases.

The successful candidate’s primary role will be one of the clinical study leads working on the plasminogen program transitioning from Phase2 to Phase3. The Director will report directly into the program clinical development strategy lead who provides the clinical research oversight of the program. The Director is expected to play a leading and influencing role in the overall clinical development strategies and drive progress and operational excellence of his/her clinical trial(s). This work will also involve extensive consultation and collaboration with external experts. The Director, Clinical Research, will work in a matrix organization across Regulatory, Biostatistics, Clinical Operations, Preclinical, Commercial & Quality Assurance teams to ensure fully harmonized and integrated development strategies. The Director will be a key Alnylam Development spokesperson at external meetings, including regulatory interactions and scientific meetings.

Key Responsibilities

• Be a subject matter expert for the relevant disease area(s)


• Be the strategic leader providing a strong, clear voice for the clinical program


• Develop creative but realistic approaches to drug development and lead clinical efforts towards global regulatory approvals


• Oversight of trial conduct and safety


• Collaborate closely with Preclinical, Regulatory Affairs and Medical Affairs to ensure tight strategic integration of product development plans.


• Be accountable via Clinical Research and Operations for all relevant timelines and deliverables.


• Supervise closely all major written deliverables (regulatory submissions, original articles, abstracts), and presentation materials.


• Be responsible for final review and sign off with respect to all controlled documents including protocols, investigator brochures, and informed consent forms.


• Influence internal and external audiences in a high impact, highly visible fashion

Qualifications

A highly driven, dynamic, engaged and accomplished physician-scientist with experience and insight will thrive in this role. Specific qualifications include:

• MD with strong research background or MDPhD with best of class clinical and/or research training as shown through research support and peer‑reviewed publications.


• Board Certification (or equivalent) or specialist training in hematology is desirable


• 3+ years industry experience or equivalent clinical academic research experience


• Sound scientific and clinical judgment


• Familiarity with concepts of clinical research and clinical trials, including biostatistics, and regulatory agency organization, guidelines, and practices


• Ability to effectively present ideas and document complex medical/clinical concepts in both written and oral communication


• History of critical thinking and problem solving while exhibiting superior judgment and a balanced, realistic understanding of issues


• Outstanding leadership and collaboration skills working within a matrix environment


• Thrives in highly entrepreneurial biotech environment and embraces Alnylam’s culture of science, passion and urgency.

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize‑winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late‑stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E‑Verify Employer.

Before applying, please review Alnylam’s Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment.

The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short‑term incentive award (e.g., bonus or sales incentive) and an annual long‑term incentive award (e.g., equity).

Pay and Compensation

• $255,000 — $345,000 USD

Benefits

• We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match.


• Eligible employees enjoy paid time off, wellness days, holidays, and two company‑wide recharge breaks.


• We also offer generous family resources and leave.


• Our commitment to your well‑being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers.