Director, Clinical Operations — First-in-Human Trials Lead

Quiet Capital; South San Francisco (CA); On-site; USD 230,000 - 340,000; Full time

Benefits offered by this job

Health Insurance

Dental Insurance

Vision Insurance

401(k) Match

Parental Leave

PTO 20 days

On-site meals

Job summary

NewLimit in South San Francisco seeks a Director / Senior Director of Clinical Operations to orchestrate and manage its first clinical trials. You will lead trial execution across multiple geographies and partner with CROs to ensure efficient, compliant study conduct.

You will build a high-performing clinical operations team, manage timelines and budgets, and support regulatory submissions to enable global trial readiness and rapid progress against ambitious healthspan goals.

Qualifications

• 10+ years of industry experience in Clinical Operations and a Bachelor’s or advanced degree in the life sciences.
• History of orchestrating clinical trials through CRO partners with accountability for operational delivery.
• Recent experience managing first-in-human trials.
• Experience managing trials across multiple geographies (US, AUS, NZ, EU, UK, Japan).
• Quantitative mindset — you track metrics, report numbers rather than anecdotes, and drive for measurable improvements quarter-over-quarter.
• Experience managing clinical trial budgets, forecasts, and resource planning.

Responsibilities

• Lead clinical trial execution through protocol development, CRO selection and management, and startup activities across several geographies (US, AUS/NZ, EU, UK).
• Collaborate with clinical development to ensure trial designs and execution provide maximum benefit to patients and maximum information per dollar.
• Manage and own company-wide clinical trial timelines and budgets, construct and instrument clinical operations metrics.
• Disentangle operational challenges that arise in trial execution — recruitment, cross-border logistics, regulatory compliance, and staffing.
• Build and manage a bar-raising clinical operations team as the founding member.
• Support regulatory submissions and ongoing global compliance obligations.

Skills

Clinical Operations

CRO management

Budget forecasting

Geography coordination

Metrics tracking

Education

Bachelor’s or advanced degree in life sciences

Tools

Regulatory submissions

Job description

NewLimit in South San Francisco seeks a Director / Senior Director of Clinical Operations to orchestrate and manage its first clinical trials. You will lead trial execution across multiple geographies and partner with CROs to ensure efficient, compliant study conduct.

You will build a high-performing clinical operations team, manage timelines and budgets, and support regulatory submissions to enable global trial readiness and rapid progress against ambitious healthspan goals.