Director, Clinical Data Management - Hybrid Leader

BioSpace; South San Francisco (CA); Hybrid; USD 232,000 - 284,000; Full time

Job summary

Maze Therapeutics is seeking a Director of Data Management to lead data management across multiple clinical trials. You will partner with Biostatistics, Clinical Operations, Regulatory Affairs, and oversee external vendors to deliver high-quality, analysis-ready data for regulatory submissions.

Reporting to the VP of Biometrics, you will set data strategy, establish standards, mentor teams, and ensure timely database locks while aligning with program goals across kidney and metabolic programs.

Qualifications

• Bachelor's or advanced degree in Life Sciences, Computer Science, or related field.
• 8+ years of clinical data management experience in biotech, pharmaceutical, or CRO environments.
• 3+ years of people and/or project leadership experience.
• Hands-on experience with EDC systems (e.g., Medidata Rave, Oracle InForm).
• Strong understanding of clinical trial operations, data flows, and regulatory expectations.
• Collaborative, mentorship-oriented leadership style with the ability to influence across teams.

Responsibilities

• Lead data management across multiple clinical studies and development phases.
• Shape and implement data management strategies, standards, and best practices.
• Mentor and support data management team members, fostering growth and knowledge sharing.
• Oversee critical study deliverables including DMPs, CRFs/eCRFs, edit checks, and database locks.
• Guide accurate, consistent, and timely clinical data collection, cleaning, and reconciliation.
• Review and approve key study documentation and ensure readiness for analysis and reporting.
• Drive database lock planning and partner closely with Biostatistics and Medical Writing to support analyses and study reports.
• Manage CROs and external vendors, ensuring clarity around timelines, quality expectations, and contractual commitments.
• Support the evaluation, implementation, and optimization of EDC and data management technologies.
• Collaborate closely with Clinical Operations, Biostatistics, and other partners across the organization.

Skills

EDC systems

Leadership

Data management

Regulatory knowledge

Cross-functional leadership

Education

Bachelor's or higher in Life Sciences/CS

Tools

Medidata Rave

Oracle InForm

Job description

Maze Therapeutics is seeking a Director of Data Management to lead data management across multiple clinical trials. You will partner with Biostatistics, Clinical Operations, Regulatory Affairs, and oversee external vendors to deliver high-quality, analysis-ready data for regulatory submissions.

Reporting to the VP of Biometrics, you will set data strategy, establish standards, mentor teams, and ensure timely database locks while aligning with program goals across kidney and metabolic programs.