Cyber Defense Incident Response Lead

Alnylam Pharmaceuticals, Inc.; Cambridge (MA); Hybrid; USD 174,000 - 236,000; Full time

Benefits offered by this job

Medical coverage

Dental coverage

Vision coverage

Life insurance

Disability insurance

401(k) with match

Paid time off

Wellness days

Holidays

Recharge breaks

Job summary

Alnylam Pharmaceuticals, a leader in RNAi therapeutics, seeks an Associate Director, Cyber Defense – Staff Incident Responder. You will lead global incident response, forensics, and threat hunting in a highly technical, hands-on role within a hybrid Cambridge, MA environment.

Reporting to the Senior Director, Cyber Defense, you will drive detection improvements, tooling, automation, and scalable response capabilities, shaping how the company detects and responds to advanced threats.

Qualifications

• 8+ years of hands-on incident response, digital forensics, threat hunting, or security operations in enterprise environments (including cloud).
• Deep investigative expertise across endpoint, cloud, network, and identity domains with multi-source telemetry correlation.
• Strong scripting and automation skills (Python, Go, PowerShell, Bash) to support scalable workflows.
• Ability to independently lead complex investigations and make high-confidence decisions under pressure.
• Familiarity with MITRE ATT&CK and industry incident response frameworks (NIST, CISA).
• Proven impact improving detection and response through tooling, processes, or programs.

Responsibilities

• Lead complex cyber investigations and incident response across global environments.
• Perform advanced forensic analysis and proactive threat hunting to identify attacker behavior.
• Translate findings into scalable improvements in detection, telemetry, and response.
• Develop incident response playbooks and containment strategies based on real threats.
• Improve response speed via detection engineering, alert tuning, and automation.
• Build and evolve incident response tooling, scripts, and integrations.
• Lead post-incident analysis and produce actionable remediation reports.
• Partner cross-functionally to drive enterprise-wide risk reduction and hardening.

Skills

Incident response

Digital forensics

Threat hunting

Cloud security

Scripting

MITRE ATT&CK

Tools

Python

PowerShell

Go

Bash

Job description

Alnylam Pharmaceuticals, a leader in RNAi therapeutics, seeks an Associate Director, Cyber Defense – Staff Incident Responder. You will lead global incident response, forensics, and threat hunting in a highly technical, hands-on role within a hybrid Cambridge, MA environment.

Reporting to the Senior Director, Cyber Defense, you will drive detection improvements, tooling, automation, and scalable response capabilities, shaping how the company detects and responds to advanced threats.