CRISPR Screening Operations Lead (Production Core)

Broad Institute of MIT and Harvard; Cambridge (MA); On-site; USD 115,000 - 162,000; Full time

Benefits offered by this job

Medical benefits

Retirement plan 401(k)

Paid holidays

Flexible spending accounts

Job summary

The Broad Institute of MIT and Harvard is seeking an experienced scientist to lead the day-to-day operation of our internal CRISPR screening platform in Cambridge, MA. This production-focused role runs large-scale screens as a reliable pipeline, working with experimental scientists, project managers, and data analysts to keep data flowing on schedule.

The ideal candidate has hands-on experience running CRISPR screens at scale in a core facility or high-throughput setting and can manage staffing,

Qualifications

• Ph.D. or equivalent in Cancer Biology or related field.
• 3+ years running large-scale CRISPR screens or high-throughput screening.
• Experience in production-oriented lab or core facility.
• Experience managing lab personnel.

Responsibilities

• Lead daily operations of large-scale CRISPR screens and other high-throughput screening workflows, treating screening as a production pipeline with defined throughput, quality, and turnaround targets.
• Develop and maintain SOPs covering experimental execution, data acquisition, and quality control.
• Manage project timelines, budgets, and resource allocation across concurrent screens.
• Supervise and mentor a team of 2+ research associates; coordinate with scientists, project managers, and analysts to keep projects on track.
• Maintain accurate records in the Laboratory Information Management System (LIMS) and ensure data is delivered in a form ready for downstream analysis.
• Continuously improve pipeline efficiency, reproducibility, and scalability as screening volume grows.

Skills

Project management

Staff management

Data analysis communication

Organizational skills

Education

Ph.D. in Cancer Biology or related field

Tools

LIMS

ELNs

Project management software

Job description

The Broad Institute of MIT and Harvard is seeking an experienced scientist to lead the day-to-day operation of our internal CRISPR screening platform in Cambridge, MA. This production-focused role runs large-scale screens as a reliable pipeline, working with experimental scientists, project managers, and data analysts to keep data flowing on schedule.

The ideal candidate has hands-on experience running CRISPR screens at scale in a core facility or high-throughput setting and can manage staffing,