Computational Genomics Scientist — Chromatin & Epigenomics

NYU Langone Health; New York (NY); On-site; USD 95,000 - 160,000; Full time

Job summary

NYU Langone Health's Skok Lab seeks a computational scientist to join a multidisciplinary program studying chromatin organization, epigenomics, and gene regulation. We recruit at either Postdoctoral Fellow or Senior Computational Biologist/Non-Tenure-Track Assistant Professor levels, depending on experience.

The role involves developing pipelines for long-read data, analyzing DNA methylation and chromatin states, and applying ML to study TF binding and RNA Pol II dynamics.

Qualifications

• PhD in a relevant quantitative or biological field.
• Strong programming skills in Python, R and Bash/Linux.
• Experience with bioinformatics, genomics, computational biology, or related analyses.
• Ability to analyze and interpret complex biological datasets.
• Interest or experience in computational epigenomics, chromatin biology, genomics, or ML.
• Ability to work independently while collaborating in a multidisciplinary team.
• Strong written and oral communication skills.

Responsibilities

• Develop and apply computational pipelines for long-read and single-molecule sequencing data.
• Analyze per-molecule DNA methylation, chromatin accessibility, and chromatin-state information.
• Apply statistical and machine-learning approaches to study nucleosome organization and TF binding.
• Integrate multi-omics datasets to investigate chromatin architecture and gene regulation.
• Develop reproducible computational workflows using Snakemake, Nextflow, or similar platforms.
• Lead or contribute to computational analyses for collaborative research projects.
• Collaborate closely with experimental scientists to integrate computational and molecular data.
• Present research findings at lab meetings, conferences, and publications.
• Develop independent computational research questions and directions.

Skills

Python

R

Bash/Linux

Bioinformatics

Computational biology

Machine learning

Education

PhD in Computational Biology, Bioinformatics, Computer Science, Statistics, Biology

Tools

Snakemake

Nextflow

Remora

Megalodon

Tombo

Job description

NYU Langone Health's Skok Lab seeks a computational scientist to join a multidisciplinary program studying chromatin organization, epigenomics, and gene regulation. We recruit at either Postdoctoral Fellow or Senior Computational Biologist/Non-Tenure-Track Assistant Professor levels, depending on experience.

The role involves developing pipelines for long-read data, analyzing DNA methylation and chromatin states, and applying ML to study TF binding and RNA Pol II dynamics.