Computational Drug Designer: AI-Driven Lead Discovery

Vertex Pharmaceuticals Incorporated

Boston (MA)

Hybrid

USD 108,000 - 162,000

Full time

6 days ago

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Job summary

Vertex Pharmaceuticals Incorporated seeks a highly motivated computational chemist to join the Computational Drug Design group in Boston. You will contribute to hit/lead identification and optimization using molecular modeling, cheminformatics, data science, and AI-enabled methods.

You will collaborate with interdisciplinary project teams to advance safe and efficacious molecules and drive innovations in AI-assisted drug discovery while working within Vertex's global Data and Computational

Qualifications

Ph.D. (or equivalent) in Computational Chemistry with 0–3 years of relevant experience.
Strong expertise in structure-based drug design.
Experience leveraging modern AI capabilities for design and discovery.
Proven success influencing teams with computational methods.
Strong programming, data analysis, and communication skills.

Responsibilities

Apply computational chemistry methods to accelerate drug discovery in collaboration with chemists, biologists, and researchers.
Utilize physics-based methods, generative models, and machine learning to design new chemical entities.
Collaborate with other computational chemists to develop workflows and share methods.
Contribute to Vertex's computational chemistry capabilities and technologies.
Work with DMPK, Structural Biology, Safety Assessment, and other groups to advance projects.