Computational Biologist - Quantitative Methods & Target Discovery

Initial Therapeutics, Inc.; Boston (MA); On-site; USD 167,000 - 266,000; Full time

Benefits offered by this job

Bonus program

401(k) plan

Comprehensive benefits

Job summary

Lilly is seeking a highly skilled computational biologist to lead analyses of multimodal biological datasets in the CardioMetabolic Research group. You will design end-to-end analyses of spatial and single-cell omics, develop predictive models, and advance causal frameworks to prioritize targets and inform portfolio decisions.

The role involves building scalable analytical pipelines, collaborating with AI teams and biologists, and contributing to novel AI approaches for drug discovery within a

Qualifications

• PhD in computational biology, biostatistics, biological engineering, systems biology, applied mathematics, or related field with analytical method development and multi-omics experience.
• 2+ years of post-doctoral or biopharma/biotech industry experience preferred.

Responsibilities

• Design and implement end-to-end analyses of multimodal omics data (spatial & single-cell) to support target discovery.
• Develop scalable pipelines for preprocessing, QC, harmonization, and integration of large datasets.
• Build predictive models combining genetic, functional, and multi-omics data to score targets and distinguish association from mechanism.

Skills

Python

R

Bayesian methods

Causal inference

Multi-omics analysis

Spatial omics

AI/ML fluency

Collaborative teamwork

Education

PhD in computational biology or related

Post-doctoral/Industry experience

Tools

Nextflow

Git

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

The Opportunity

This is anindividual contributor role in Boston or Indianapolis for an experiencedcomputational biologist who will lead analyses of multimodal biological datasets and develop methods that advance target discovery in cardiometabolic diseases. The role, in the Data Science team in CardioMetabolic Research (CMR) at the intersection of spatial and single-cell omics, causal inference, AI/ML, and functional genomics.

The scientist in this role will independently design and implement end-to-end analyses of spatial and single-cell transcriptomic, proteomic, and metabolomic datasets, as well as functional genomics workstreams. In a team setting they will integrate results across modalities and with genetic evidence to build convergent frameworks for target prioritization, and develop predictive models to score targets, distinguish association from mechanism, and provide measures of confidence that inform portfolio decisions.

The role also involves advancing the team's quantitative toolkit — introducingML/AI approaches,knowledge graphs,Bayesian methods,andcausal modeling where they contribute — and influencing the data architecture and analytical standards that support reproducible, scalable science. The scientist willcollaborate withinternal AI teams,data engineering teams,translational biology teams, statistical geneticists, and statisticians toleverageand co-develop models for drugdiscovery andwillrepresentcomputational innovation with CMR and across the broader organization.

This role suits a scientist who combines depth in computation withthe independenceto drive programs and the collaborative instinct to elevate the work of those around them.

Who we are looking for

Someone wholoveshands-on computational work and holds strong,experience-driven experience opinions on methods. A scientist who leads throughscientific influence: advising colleagues, raising analytical standards, and improving the science around them. The right candidate is drawn to connecting genetic evidence, public multi-omics data, and experimental model data to functional biology — building causal frameworks around targets and delivering measures of confidence and uncertainty that inform decisions on targets and molecules. They collaborate well with statisticians — adapting methods from other domains, co-developingnew approaches, or stress-testing an existing framework to find where it breaks. They are pragmatic about methods: they know when a Bayesian model is worth the investment and when a simpler approach will do. They have enough AI and ML fluency — from agentic systems for routine tasks to foundation models and graph neural networks for complex problems — to work productively with AI teams and translate those capabilities intoCMRscience. Ideally, they are also motivated to build novel AImodels themselvesto advance drug discovery.Above all, theywant to be part of a teammotivatedtobuilda robust platformtogether.

What You'll Do

Multimodal Omics & Functional Genomics

• Design and implement single cell and spatial omics analyses integrating imaging-based, sequencing-based, and multiplexed platforms to characterize changes in tissue architecture, cellular neighborhoods, and microenvironmental as well as system-level dynamics
• Build scalable pipelines to preprocess, QC, harmonize, and integrate large-scale spatial and molecular omics datasets, enabling discovery-ready data layers and downstream modeling
• Hands-on end-to-end analysis of functional genomics workstreams (CRISPR screens, perturb-seq, high-content perturbation readouts) and integrate results with transcriptomic, proteomic, and pathway-level data for target prioritization
• Ingest,developand apply advanced AI/ML, statistical, and computational frameworks to analyze single-cell, spatial transcriptomic, proteomic, metabolomic, and multi-omics datasets at scale

Collaboration with Discovery,Translational & Geneticsteams

• Partner closely with pre-clinical bench scientists and translational biologists in CMR to frame questions, design experiments with statistical rigor, and translate computational results into target discovery decisions
• Consume and interpret outputs from statistical genetics and integrate them with functional and molecular data to build convergent evidence frameworks for target nomination
• Develop predictive models that combine genetic, functional, and multi-omics evidence to score and rank targets, using causal reasoning to distinguish association from mechanism
• Contribute to virtual patient and disease modeling approaches where multi-omics and mechanistic evidence converge to support target validation and translational hypotheses

Computational Methods & Platform Development

• Apply and introduce modern quantitative methods — Bayesian modeling, causalinferenceand causal graph modeling, mechanistic or agent-based modeling, knowledge graphs, ML/AI for target discovery and scoring — with pragmatic judgment about when each approach adds genuine value
• Evaluate and integrate novel AI approaches for multi-omics data analysis, including graph-based methods, generative models, representation learning, and foundation models
• Influence the design and implementation ofscalable, reproducible analytical workflows for high-dimensional, multimodal data integration — contributing to the broader computational and data architecture that supports next-generation omics and ML workloads
• Influence data architecture, pipeline design, and analytical platform standards in collaboration with data engineering and infrastructure teams

Cross-Functional Influence

• Work with internal AI teams, statistics teams, and Lilly Research Nucleus toleverageinternally built models and co-develop new computational approaches for drug discovery
• Champion standards in analytical rigor, reproducibility, and documentation across the computational biology community within and outside of CMR
• Advise fellow computational biologists through code review, collaborative analysis, and shared problem-solving

What You Bring

Minimumrequirements:

• Ph.D. in computational biology, biostatistics, biological engineering, systems biology, applied mathematics, or a quantitative life science field, with training or research experience that combines analytical method development (Bayesian approaches, AI/ML,etc. )with applied work in multi-omics, spatial omics, or functional genomics

Preferred

• 2+ years of post-doctoral or biopharma/biotech industry experience
• Experience with spatial omics platforms (spatial transcriptomics, multiplexed imaging, spatial proteomics), single-cell RNA-seq, proteomics, metabolomics, or multi-omics data integration
• Proficiencyin Python and/or R with solid software practices — version control, documentation, reproducible workflows — and familiarity with scientific computing libraries
• Familiarity with workflow orchestration (e.g., Nextflow), cloud-native analytical environments, and data architecture in a research organization
• Demonstrated ability to analyze, integrate, and interpret large-scale, multimodal datasets, including experience designing scalable analytical pipelines
• Demonstrated experience in at least two of: Bayesian methods (e.g.,PyMC, Stan), causal modeling, knowledge graph approaches, ML/AI applied to biological target discovery,causal inference methods,orfunctional genomics data analysis at scale
• Ability to critically interpret statistical genetics outputs and integrate them with molecular and functional data — you do not need to run GWAS, but you need to know what the outputs mean and how to use them
• History of embedded collaboration with experimental scientists, statisticians, AI teams, or other computational scientists across organizational boundaries
• Experience building predictive models or integrative evidence frameworks that combine genetic and functional data for target scoring
• Experience developing or contributing to novel ML/AI models or statistical or algorithmic approaches in a biological context
• Track recordof leading through scientific influence — independently owning complex research programs, setting technical direction, and shaping priorities across teams without direct management authority
• Strong publication record in peer-reviewed journals or ML/AI venues, reflecting methodological innovation in computational biology, multi-omics analysis, or applied machine learning

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$166,500 - $266,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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