Co-Founder & AI-Driven Protein Design Scientist

Helix BioSearch; Boston (MA); On-site; USD 200,000 - 300,000; Full time

Benefits offered by this job

Meaningful equity

Job summary

Helix BioSearch is seeking a Co-Founder or Founding Scientist to build an AI-native immunotherapy discovery platform from the ground up in collaboration with a stealth-mode biotech partner.

You will lead computational strategies for antibody/TCR design, sequence optimization and structure-function prediction, translating insights into experimental designs and shaping the platform’s technical roadmap.

Qualifications

• PhD or equivalent research experience in ML, computational biology, bioinformatics, CS, protein engineering, structural biology or related field.
• At least 2 years of industry or postdoc experience; open to early-career scientists to senior leaders.
• Hands-on experience applying AI/ML to biological problems.
• Strong understanding of protein engineering (CARs, antibodies, TCRs or related) and experience with sequence/structure data.
• Experience with protein language models, generative models, deep learning, representation learning, sequence optimization or structure-based modeling.
• Strong programming skills in Python and modern ML frameworks.

Responsibilities

• Develop and apply machine learning and AI models for therapeutic protein engineering and discovery.
• Work with biological sequence and structural data to build predictive and generative protein design approaches.
• Apply computational methods to antibody, TCR or related biologic engineering.
• Develop models for sequence-function relationships, affinity, specificity, developability, immunogenicity and other properties.
• Partner with experimental scientists to translate predictions into designs.
• Establish the company’s AI/ML and computational protein engineering strategy.
• Evaluate emerging advances in generative AI, protein language models, structure prediction and related tech.
• Contribute to the design of the computational platform and scientific roadmap.
• Help shape future hiring and research priorities as an early scientific leader.

Skills

PhD expertise

ML model development

Protein engineering

Python programming

Cross-functional leadership

Education

PhD or equivalent

Tools

Python

ML frameworks

Sequence data tools

Job description

Helix BioSearch is seeking a Co-Founder or Founding Scientist to build an AI-native immunotherapy discovery platform from the ground up in collaboration with a stealth-mode biotech partner.

You will lead computational strategies for antibody/TCR design, sequence optimization and structure-function prediction, translating insights into experimental designs and shaping the platform’s technical roadmap.