Antibody Engineering

Chai Discovery; San Francisco (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Highly competitive compensation

Opportunity to work with world-class people

Culture of high velocity and ownership

Job summary

A pioneering applied research lab in San Francisco seeks exceptional antibody engineers to drive innovations in therapeutic design. You will join an elite team working alongside biologists and AI researchers to enhance antibody design capabilities. Ideal candidates possess a PhD and relevant hands-on experience, with strong collaborative skills. This role offers exposure to cutting-edge scientific challenges and the chance to influence the future of medicine while enjoying competitive compensation and a high-ownership culture.

Qualifications

• PhD or equivalent experience in Antibody Engineering, Computational Biology, or Protein Sciences.
• Hands-on experience with antibody-based biologics and molecular-biology workflows.
• Strong track record in communication, collaboration, and execution.

Responsibilities

• Evaluate and apply capabilities of antibody design models.
• Work closely with biologists, computational scientists, and AI researchers.
• Execute experimental programs at scale.

Skills

Antibody Engineering

Computational Biology

Protein Sciences

Molecular Biology

Communication

Collaboration

Execution

Education

PhD or equivalent

Tools

PyMOL

Job description

About Chai Discovery

Chai Discovery is an applied research lab working on the future of medicine. Our product is a design suite for molecules, built on our frontier models. We help scientists develop drugs with engineering precision, unlocking better medicines for humanity.

Our founders have been at the forefront of this field since its inception. We have raised $230m from Thrive, General Catalyst, OpenAI, Dimension and other tier‑one investors. We partner with global life sciences companies like Eli Lilly, who have made multi‑year, eight‑figure annual revenue commitments to our platform.

We are known for talent density, rigorous research and pace of execution.

About the role

We are looking for exceptional antibody engineers and computational protein designers to help us evaluate, expand and apply the capabilities of our de novo antibody design models. You'll join an elite team of biologists, computational scientists and AI researchers.

Scientists at Chai are power users and test pilots of our AI platform. We probe the design space for novel targets and formats, validate in silico solutions for function in the lab, and distill empirical rules from the results. We execute experimental programs at scale that guide, train and evaluate next generation models, working closey with our AI research team. We partner with scientists from the world's leading pharma companies to push their discovery programs into new territory. I think you could be a good fit.

This is an opportunity to push the boundaries of applied biology and artificial intelligence. You'll get exposed to a wide array of scientific problems and research methods, far beyond what one encounters working on a single drug program or within a traditional life sciences company.

About you

You have a deep desire to push the limits of what’s possible in therapeutic design, and a restless drive to solve real‑world problems and iterate quickly. You are curious, high‑agency and incredibly persistent.

• PhD or equivalent experience in the field—Antibody Engineering, Computational Biology, Protein Sciences.

• Hands‑on experience with design and characterization of antibody‑based biologics. Proficient in molecular‑biology workflows, binding and developability assays, inspecting structures in PyMOL or similar tools.

• Track record of strong communication, collaboration and execution.

We offer

The opportunity to work at the frontier of AI, with world‑class people, on a mission that matters. We protect & promote a culture of high velocity and ownership. We offer highly competitive compensation.