CNS Drug Product Formulation Director (Phase I-III)

Scorpion Therapeutics; Boston (MA); On-site; USD 170,000 - 210,000; Full time

Job summary

Centessa's CMC group is seeking an Associate Director of Drug Product to lead formulation development for early-stage small molecule programs, with a focus on neurological indications such as narcolepsy.

The role oversees nonclinical and clinical formulation, manages CROs/CDMOs, guides physiochemical characterization, pre-formulation, stability, and compatibility studies, and collaborates with discovery, nonclinical, clinical, and regulatory teams.

Qualifications

• BS/MS in Pharmaceutical Sciences or related; PhD preferred.
• 10+ years in small molecule formulation development for Phase I–III.
• Experience with poorly soluble (BCS II/IV) compounds.
• Expertise in liquid and solid dosage forms.
• Experience managing external vendors and working with cGMP.

Responsibilities

• Oversee nonclinical and clinical formulation development; manage CROs/CDMOs.
• Guide physiochemical characterization, pre-formulation, stability, and compatibility studies.
• Support clinical formulation efforts; author and review development documentation.
• Coordinate shipments and regulatory submissions; collaborate with cross-functional teams.

Skills

Formulation development leadership

Education

BS/MS in Pharmaceutical Sciences or related

PhD preferred

Tools

HPLC

XRPD

DSC

TGA

DVS

Job description

Centessa's CMC group is seeking an Associate Director of Drug Product to lead formulation development for early-stage small molecule programs, with a focus on neurological indications such as narcolepsy.

The role oversees nonclinical and clinical formulation, manages CROs/CDMOs, guides physiochemical characterization, pre-formulation, stability, and compatibility studies, and collaborates with discovery, nonclinical, clinical, and regulatory teams.