Associate Director, Drug Product - CMC

Scorpion Therapeutics; Boston (MA); On-site; USD 170,000 - 210,000; Full time

Job summary

Centessa's CMC group is seeking an Associate Director of Drug Product to lead formulation development for early-stage small molecule programs, with a focus on neurological indications such as narcolepsy.

The role oversees nonclinical and clinical formulation, manages CROs/CDMOs, guides physiochemical characterization, pre-formulation, stability, and compatibility studies, and collaborates with discovery, nonclinical, clinical, and regulatory teams.

Qualifications

• BS/MS in Pharmaceutical Sciences or related; PhD preferred.
• 10+ years in small molecule formulation development for Phase I–III.
• Experience with poorly soluble (BCS II/IV) compounds.
• Expertise in liquid and solid dosage forms.
• Experience managing external vendors and working with cGMP.

Responsibilities

• Oversee nonclinical and clinical formulation development; manage CROs/CDMOs.
• Guide physiochemical characterization, pre-formulation, stability, and compatibility studies.
• Support clinical formulation efforts; author and review development documentation.
• Coordinate shipments and regulatory submissions; collaborate with cross-functional teams.

Skills

Formulation development leadership

Education

BS/MS in Pharmaceutical Sciences or related

PhD preferred

Tools

HPLC

XRPD

DSC

TGA

DVS

Job description

Role: Associate Director of Drug Product within Centessa's CMC group, supporting early-stage small molecule programs, particularly for neurological indications like narcolepsy.

Responsibilities: oversee nonclinical and clinical formulation development, manage CROs/CDMOs, guide physiochemical characterization, pre-formulation, stability, and compatibility studies; support clinical formulation efforts; author and review development documentation; coordinate shipments and regulatory submissions; collaborate with cross-functional teams (discovery, nonclinical, clinical, regulatory).

Requirements: BS/MS in Pharmaceutical Sciences or related; PhD preferred; 10+ years in small molecule formulation development supporting Phase I-III; expertise in poorly soluble (BCS II/IV) compounds, liquid and solid dosage forms, analytical techniques (HPLC, XRPD, DSC, TGA, DVS); experience managing external vendors and working within cGMP standards.

HighValue: small molecule drugs, neurological indications (narcolepsy, hypersomnia), Phase I-III, nonclinical and clinical formulation, cGMP, vendor oversight.

WorkSetup: based in US, with occasional domestic/international travel (5-10%).