Clinical Research Program Lead - Inflammatory Diseases

1200 The General Hospital Corporation; Boston (MA); On-site; USD 63,000 - 103,000; Full time

Job summary

Mass General Brigham is seeking a Clinical Research Program Manager to lead the clinical research operations of a multidisciplinary program investigating inflammatory diseases. You will coordinate studies, oversee biospecimen handling, and work with investigators across institutions to translate findings into improved patient interventions.

The role requires strategic leadership, experience in managing human subjects research, and collaboration with Broad Institute researchers, with onsite

Qualifications

• Bachelor’s degree in a related field required.
• Master’s degree preferred in public health, biology, or clinical research.
• Can this role accept experience in lieu of a degree? No

Responsibilities

• Manage the day-to-day operations of multiple clinical research studies in inflammatory and immune‑mediated conditions.
• Design, initiate, and implement human subjects research protocols and safety monitoring plans.
• Directly supervise, train, and support Clinical Research Coordinators and other study staff, including oversight of patient recruitment, medical‑record abstraction, biospecimen acquisition and processing, and data quality.
• Coordinate study initiation and start‑up activities and help ensure that regulatory, operational, and scientific requirements are addressed efficiently.
• Prepare and submit human subjects research protocols, amendments, continuing reviews, and related materials to the Institutional Review Board (IRB).
• Develop study operations manuals, standard operating procedures, Case Report Forms, and other study documentation.
• Establish project plans, forecast milestones, track progress, identify risks and dependencies, and ensure that projects remain aligned with scientific and leadership goals.
• Report study progress at investigator and project meetings and prepare study‑related reports for research teams, funding organizations, and regulatory agencies.
• Oversee clinical research databases and workflows to ensure the quality, integrity, and appropriate handling of clinical and research data.
• Coordinate the collection, processing, tracking, and transfer of biospecimens used for genomic, transcriptomic, immunologic, microbiome, metabolomic, single‑cell, spatial, and other molecular analyses.
• Facilitate approved sharing of data and biospecimens with collaborators in accordance with study protocols, Data Use Agreements, and institutional requirements.
• Partner closely with researchers at the Broad Institute to connect clinical cohorts and biospecimens with advanced experimental and computational research.
• Participate in the development and implementation of recruitment strategies for clinical studies.
• Oversee study budgets and associated research expenditures and coordinate subcontracts or other agreements with participating institutions as needed.
• Develop and maintain policies, procedures, and systems that support consistent, high‑quality clinical research operations.
• Identify operational challenges, anticipate study needs, and independently develop practical solutions that allow clinical and scientific teams to work effectively.

Skills

Strategic planning

Decision making

Organizational skills

Communication skills

Team supervision

Cross-functional collaboration

Data management

Education

Bachelor’s degree in a related field

Master’s degree in public health, biology, clinical research, or related field

Can this role accept experience in lieu of a degree? No

Job description

Mass General Brigham is seeking a Clinical Research Program Manager to lead the clinical research operations of a multidisciplinary program investigating inflammatory diseases. You will coordinate studies, oversee biospecimen handling, and work with investigators across institutions to translate findings into improved patient interventions.

The role requires strategic leadership, experience in managing human subjects research, and collaboration with Broad Institute researchers, with onsite