Clinical PK/PD Strategy Lead | Remote

Crossing Hurdles; United States; Remote; USD 241,080 - 344,400; Part time

Job summary

A health care consultancy is seeking a PK/PD Module Expert to work remotely on a contract basis. The expert will develop first-in-human dose rationales, translate pharmacological decisions into AI training, and document decision-making rules. This role requires deep knowledge in translational pharmacology, particularly in biopharma environments, strong communication skills, and experience in clinical governance. Ideal candidates will be comfortable functioning independently within a project-based setup.

Qualifications

• Strong experience in translational or clinical pharmacology within major biopharma or biotech.
• Proven experience in FIH dose selection and governance boards including IND sign-off.
• Ability to articulate decision-making balancing safety, pharmacology, and proof-speed.

Responsibilities

• Develop FIH dose rationales and escalation strategies for drug programs.
• Translate pharmacology into structured guidance for AI.
• Collaborate with AI researchers on clinical pharmacology decisions.

Skills

Translational pharmacology

Clinical pharmacology

Dose justification

Written communication

Independent project work

Job description

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This range is provided by Crossing Hurdles. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$175.00/hr - $250.00/hr

Position: PK/PD Module Expert – Translational / Clinical Pharmacology Decision-Maker

Type: Hourly contract

Compensation: $175–$250/hour

Location: Remote

Commitment: 10–40 hours/week

Responsibilities

• Develop gold-standard First-in-Human (FIH) dose rationales and escalation strategies for representative drug programs.
• Translate real-world translational pharmacology decision-making into structured guidance for AI training and evaluation.
• Encode decision heuristics, trade-offs, and governance-level judgment into clear rubrics and decision rules.
• Evaluate AI-generated PK/PD and dose-selection outputs for scientific rigor, safety, and decision quality.
• Surface and document unwritten decision rules used by senior translational leaders when overriding model-based recommendations.
• Collaborate asynchronously with AI researchers to refine model reasoning around clinical pharmacology decisions.

Qualifications

• Strong experience in translational or clinical pharmacology within major biopharma, biotech, or specialized consulting environments.
• Direct ownership of FIH starting dose selection, SAD/MAD design, and Phase 2 dose selection for multiple assets.
• Proven experience participating in governance or review boards, including IND sign-off and dose-justification defense.
• Deep understanding of nonclinical-to-clinical translation, including tox, PK, PD, potency, and mechanism of action.
• Ability to articulate real-world decision calculus balancing safety, pharmacology, and speed-to-proof.
• Strong written communication skills with the ability to convert expert judgment into explicit rules and rubrics.
• Comfortable working independently in a remote, project-based environment.

Application Process

• Upload resume
• Interview (15 min)

Job details

• Seniority level: Associate
• Employment type: Contract
• Job function: Health Care Provider
• Industries: Hospitals and Health Care

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