Clinical Development Leader, Epilepsies

Praxis Precision Medicines; United States; Remote; USD 280,000 - 350,000; Full time

Benefits offered by this job

Medical, dental and vision coverage

Life insurance

Disability benefits

401(k) match

Stock incentives

ESPP

Job summary

Praxis Precision Medicines is seeking a senior clinical leader to drive epilepsy programs across adults and pediatrics. You will own development strategy, lead studies from design through execution, and interact with regulatory authorities.

This hands-on role requires deep epilepsy experience, ownership mindset, and the ability to guide teams across clinical operations, biostatistics, safety, and regulatory.

Qualifications

• Led clinical trials or major development decisions personally.
• Experience with regulatory submissions (IND/CTA/ NDA/MAA) and health authority interactions.
• Strong judgment to make timely calls on emerging data.
• Comfort in dynamic environment with shifting priorities.
• Ownership mindset and ability to develop other leaders.

Responsibilities

• Lead epilepsy program development from strategy through execution.
• Own regulatory filings and prepare materials for health authorities.
• Drive cross-functional teams across clinical ops, biostatistics, regulatory, safety.
• Translate data and patient needs into development strategy.
• Represent Praxis with investigators and partners.

Skills

Clinical leadership

Regulatory submissions ownership

Trial design & execution

Cross-functional collaboration

Data interpretation & decision making

Regulatory strategy

Education

Advanced scientific degree (MD, PhD, or PharmD) in a relevant field

Job description

Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed.

The Opportunity

Turning promising science into better treatments for epilepsy takes more than expertise. It takes ownership, sound judgment, and the drive to lead trials and translate emerging data into decisions that move medicines forward for the patients we serve. At Praxis, you’ll take clinical leadership across our epilepsy portfolio, spanning adult programs and pediatric studies. You’ll shape development strategy, lead studies, interpret emerging data, drive cross-functional execution, and carry clinical strategy through regulatory submissions and health authority interactions. This is a role for someone who is hands‑on and wants to lead the work, not just review and advise on the work of others. You bring deep epilepsy development experience while also helping build the capabilities of other clinical leaders across the portfolio.

Primary Responsibilities

• Epilepsy development: Apply deep understanding of adult and pediatric epilepsy, trial design, endpoints, and the regulatory pathway – including pediatric requirements such as PIP and PSP – to development strategy and decision‑making.
• Clinical strategy and trials: Translate science, emerging data, patient need, and regulatory requirements into development strategies – and personally lead studies from design through execution.
• Data‑driven decisions: Interpret emerging clinical and scientific data, identify what matters, and make timely calls when information is incomplete.
• Regulatory strategy: Own substantive clinical content for regulatory filings, briefing materials, and health authority interactions.
• Cross‑functional leadership: Drive teams across clinical operations, biostatistics, regulatory, safety and other disciplines to resolve issues and move programs forward.
• Team development: Bring your program and submission experience to strengthen other clinical leaders, expanding their judgment, ownership, and ability to lead increasingly complex development work.
• External leadership: Represent Praxis credibly with investigators, KOLs, health authorities, and partners.

Qualifications and Key Success Factors

• An advanced scientific degree (MD, PharmD, PhD, or equivalent) is required.
• A track record of clinical trials, programs, submissions, or major development decisions that you personally led.
• Regulatory submission ownership having carried the clinical content of IND, CTA, NDA, or MAA filings, briefing books, and health authority interactions.
• Strong judgment and the ability to make thoughtful, timely calls on emerging data with incomplete information and the knowledge of what to elevate and when.
• Comfort operating in a dynamic environment where priorities shift, scope evolves, and ownership matters more than rigid role boundaries.
• You’ll thrive here if you take ownership, challenge assumptions with scientific rigor, move with urgency without sacrificing quality, and stay focused on outcomes that matter for patients.
• Thrives in a dynamic environment where priorities shift, scope evolves, and ownership matters more than rigid role boundaries.

The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.

Annualized Base Salary

$280,000—$350,000 USD

Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage.Thinking about the future? We match dollar‑for‑dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long‑term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company‑wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!

Company Overview

Praxis Precision Medicines is a clinical‑stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.

Diversity, Equity & Inclusion

Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.