Chemist I/II/III

Bachem Holding AG; Torrance (CA); On-site; USD 80,000 - 120,000; Full time

Benefits offered by this job

Medical/Dental/Vision coverage

401(k) plan with employer contribution

Paid vacation

Personal and sick days

Annual performance bonus

Job summary

Bachem Americas in Torrance, CA is seeking a Chemist to manufacture APIs in a cGMP environment and perform related activities. The role covers equipment operation, in-process testing and process development within a fast-paced setting.

Responsibilities include synthesis, purification, batch records, material coordination, and maintaining GMP documentation. Strong communication, teamwork and ability to handle hazardous materials are essential.

Qualifications

• Bachelor’s degree in chemistry or related field or 10+ years experience in GMP manufacturing.
• Experience with GMP and FDA regulations is preferred.
• Experience in manufacture of peptides and oligonucleotides is preferred.
• Capable of following GMP guidelines and housekeeping rules.
• Excellent written and oral communication skills.
• Ability to work well in a team and communicate proactively.
• Ability to accommodate four 10-hour shift schedules weekly (start times 5:00am–3:00pm).
• Ability to organize, multitask and work in a fast-paced environment.
• Basic computer knowledge including Word, Excel and PowerPoint.
• Ability to work with hazardous materials and chemicals.

Responsibilities

• Install, operate and maintain equipment for manufacturing and in-process testing (HPLC/UPLC, lyophilizers, balances, reactors, HF cleavage equipment, diafiltration systems, water purification systems, ovens, washing systems).
• Perform solid and liquid phase synthesis, deprotect and cleave API from resin using chemical cocktails.
• Perform purification via chromatography, crystallization and other techniques.
• Follow GMP directions using Master Batch Records, SOPs, STPs and related GMP documents.
• Coordinate raw material orders, QA/QC, and inventory, and monitor material release.
• Maintain GMP Documentation System; investigate deviations and produce reports; support document change requests.
• Maintain/organize work areas and equipment within the manufacturing facility.
• Write and improve SOPs, STMs, MBPRs and related GMP documents.
• Follow SOPs to clean equipment and maintain cleaning logs; dispose chemical waste.
• Monitor maintenance and cleaning procedures by reviewing and signing logs.

Skills

Communication

Teamwork

Time management

Multitasking

Detail oriented

Troubleshooting

MS Office

Education

Bachelor’s degree in chemistry or related field

10+ years relevant GMP experience

Tools

HPLC/UPLC

Lyophilizers

Diafiltration systems

Water purification systems

Job description

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The role of the Chemist is to manufacture active pharmaceutical ingredients (APIs) and perform related activities within a cGMP regulated environment.

What you will do

• Install, operate and maintain equipment for manufacturing and in-process testing (HPLC/UPLC, lyophilizers, balances, reactors, HF cleavage equipment, diafiltration systems, water purification systems, ovens, washing systems, et al.)
• Perform solid phase and liquid phase synthesis, deprotect and cleave the API from the resin using chemical cocktails, containing HF, TFA, ammonium hydroxide or other chemicals
• Perform purification process via chromatography, crystallization and other techniques
• Follow approved GMP manufacture directions such as Master Batch Records, Standard Operation Procedures, Standard Test Procedures and other procedures to manufacture GMP materials, perform in-process test, package the product including other related activities
• Perform project-planning and initiate raw material order-request. Receive raw materials, coordinate with QA/QC and Material Management for material release and monitor raw material inventories
• Follow and maintain GMP Documentation System; Investigate deviations and produce reports; Initiate document change request; Assist quality control and assurance unit to maintain equipment calibration program
• Maintain/organize work areas (hood, bench, floor, wall, etc.) and other designated areas within the manufacturing facility
• Write and improve Standard Operation Procedures (SOP), Standard Test Procedures (STM), Master Batch Records (MBPR) and other related GMP documents
• Follow SOPs and approved directions to clean equipment used in GMP processes, maintain cleaning log for each equipment, assist in equipment calibration program, and dispose chemical waste generated in the manufacture
• Monitor compliance of maintenance and cleaning procedures of equipment and instruments used in GMP processes by periodically reviewing and signing off on maintenance and cleaning log for each equipment

Qualifications

• Bachelor’s degree in chemistry or related field (in lieu of degree, will consider 10+ years relevant experience)
• Experience in GMP manufacturing as well as basic knowledge of cGMP and FDA regulations (preferred)
• Experience in the manufacture of peptides and oligonucleotides (preferred)
• Capable of following GMP guidelines and housekeeping rules
• Excellent written and oral communication skills
• Communicate effectively and ability to function well in a team environment
• Ability to communicate in a proactive and solution-focused manner, including keeping direct supervisor aware of potential issues.
• Ability to accommodate four 10-hour shift schedules each week with start times as early as 5:00am or as late as 3:00pm (including either a Saturday or Sunday)
• Ability to work independently and manage one’s time
• Ability to effectively organize, multitask, and work in a fast-paced, deadline driven work environment
• Detail oriented with the ability to troubleshoot and resolve problems
• Basic computer knowledge, including Microsoft Word, Excel and PowerPoint
• Ability to work with hazardous materials and chemicals

Base Hourly Ranges:

Placement of new hires in these wage ranges is based on several factors including education, skill sets, experience, and training.

Total Rewards

We offer all Team Members a total rewards package including competitive pay, annual performance bonus, a generous benefit package with comprehensive Medical/Dental/Vision coverage, 401(k) plan with employer contribution, and paid vacation, personal and sick days.

Corporate Social Responsibility

Bachem takes responsibility for future generations by a careful handling of resources and avoiding environmental risks. We continually improve our ecological performance and develop and implement new approaches for enhancing employees’ environmental awareness. EcoVadis has awarded Bachem Gold Medal status in their assessment of Bachem.

Bachem Americas is an Equal Opportunity Employer

As an equal opportunity employer, we celebrate the diversity of our team and are committed to building an inclusive workplace where individuals are hired and advanced based on merit, skills, and qualifications. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status, or other legally protected status.