Cell Line Development Scientist

Demeetra; Lexington (KY); On-site; USD 110,000 - 150,000; Full time

Job summary

Demeetra is seeking highly motivated Cell Line Development Scientists to join our fast-paced team advancing next-generation gene editing technologies in bioproduction. This role is designed for someone who is eager, hands-on, detail-driven, and experienced enough to contribute with minimal onboard training.

You will develop engineered CHO cell lines and optimize upstream processes that support Demeetra’s cutting-edge gene editing platforms, with 1–2 years of tissue culture experience preferred.

Qualifications

• PhD in biology, biochemistry, biotechnology, or related field.
• 1–2+ years tissue culture experience in CLD/CDMO setting preferred.
• Proficient in CHO cell culture, shake flask and SpinTube fed-batch processes.
• Experience with cloning, titer assessment, and basic downstream QC (HPLC a plus).
• Ability to thrive in a fast-moving, high-expectation environment.

Responsibilities

• Execute CHO cell culture across shake flasks and SpinTube formats.
• Perform transfection, selection, clone screening, and single-cell cloning workflows.
• Support upstream development with data integrity and process consistency.
• Run titer and basic downstream quality assays to assess productivity.
• Collaborate cross-functionally to implement advanced gene editing in CLD.
• Contribute to workflow design, documentation, and continuous improvement.
• Maintain a culture of excellence and timely delivery.

Skills

1-2 years tissue culture experience

CHO cell culture

Shake flask fed-batch

Single-cell cloning

Titer determination

HPLC experience

Education

PhD in biology/biochemistry/biotechnology

Job description

Demeetra is seeking highly motivated Cell Line Development Scientists to join our fast-paced team advancing next-generation gene editing technologies in bioproduction. This role is designed for someone who is eager, hands-on, detail-driven, and experienced enough to contribute with minimal onboard training. The successful candidate must be driven by a culture of excellence and ready for intense, high-expectation, hands-on CLD workflows, bringing industry experience that enables them to contribute at a high level from day one, ideally in a CRO or CDMO setting.

About the Role

You will be a key contributor in developing engineered CHO cell lines and optimizing upstream processes that support Demeetra’s cutting-edge gene editing platforms. This position is ideal for recent graduates who preferably have 1-2 years of cell culture experience, and are eager to take ownership of experimental design, workflow execution, and timeline-driven deliverables.

Responsibilities

• Execute CHO cell culture processes across shake flasks and SpinTube formats
• Perform transfection, selection, clone screening, and single-cell cloning workflows
• Support upstream development with high attention to process consistency and data integrity
• Run titer and basic downstream quality assays to assess productivity and cell line performance
• Collaborate cross-functionally to implement advanced gene editing technologies in CLD
• Contribute to workflow design, documentation, and continuous process improvement
• Maintain a culture of excellence, accountability, and meeting or exceeding timelines

Required Qualifications

• PhD in biology, biochemistry, biotechnology, or related field required
• 1–2+ years tissue culture experience in cell line development or upstream processing (CDMO or CLD company strongly preferred)
• Demonstrated proficiency in:
• CHO cell culture
• Shake flask and SpinTube fed-batch processes
• Single-cell cloning
• Titer determination and standard downstream quality assessments (HPLC experience is a plus)
• Ability to thrive in a high-expectation, fast-moving environment
• Strong communication, organization, and documentation skills

Why Join Demeetra?

This is an opportunity to join a growing company at the forefront of gene editing applied to cell line development and bioprocessing. You will have significant hands-on impact, work with advanced technologies, and be part of an intensely collaborative and rewarding environment.