Caltech Postdoc Position

Instruct-ERIC; Pasadena (CA); On-site; USD 70,000 - 90,000; Full time

Job summary

The Hoelz laboratory at California Institute of Technology seeks a postdoctoral scientist in structural cell biology to study the nuclear pore complex, combining X-ray crystallography, cryo-electron microscopy, biochemistry, and biophysics with cell biology experiments to relate structure to function. This position requires a recent Ph.D.

in biochemistry or biophysics with a strong background in X-ray crystallography, cryo-EM/tomography, and/or cell biology, and a proven track record of

Qualifications

• Ph.D. in biochemistry or biophysics.
• Strong background in X-ray crystallography, cryo-EM/tomography and/or cell biology.
• Proven productivity with first-author publications.

Responsibilities

• Conduct structural biology research on the nuclear pore complex.
• Apply X-ray crystallography and cryo-EM to relate structure to function.
• Collaborate across biochemistry, biophysics, and cell biology to advance the project.

Skills

biochemistry

X-ray crystallography

cryo-EM

cell biology

biophysics

Education

Ph.D. in biochemistry or biophysics

Job description

Jobs in Structural Biology and Related Fields

California Institute of Technology, Pasadena, CA 91125-7200, United States

The Hoelz laboratory at the California Institute of Technology seeks to recruit an outstanding postdoctoral scientist in structural cell biology. Their laboratory studies the nuclear pore complex and the associated nucleocytoplasmic transport machinery, combining X-ray crystallography, single-particle cryo-electron microscopy, biochemistry, and biophysical studies with cell biology experiments to relate structure to function.

This position requires a recent Ph.D. in biochemistry or biophysics with a strong background in biochemistry, X-ray crystallography, cryo-electron microscopy/tomography, and/or cell biology. The successful candidate will be a highly motivated individual with excellent organizational, communication, and interpersonal skills and a proven track record of scientific excellence and productivity, as demonstrated by a strong publication record that includes first-author publications.

The laboratory is well funded and equipped with modern instrumentation. Importantly, Caltech has exceptional infrastructure for structural biology.

The position is available immediately and is fully funded for multiple years.

Selected Publications

Mobbs, G.W.,# Petrovic, S.,# Hoelz, A.* (2026). Nucleocytoplasmic transport.Annu. Rev. Biochem.95, 247–290.

Petrovic, S.,# Mobbs, G.W.,# Hoelz, A.* (2026). Structure, function and assembly of nuclear pore complexes.Nat. Rev. Mol. Cell Biol.27, 35–54.

Petrovic, S., Samanta, D., Perriches, T., Bley, C.J., Thierbach, K., Brown, B., Nie, S., Mobbs, G.W., Stevens, T.A., Liu, X., Tomaleri, G.P., Schaus, L., Hoelz, A.* (2022). Architecture of the linker-scaffold in the nuclear pore.Science376, eabm9798.

Bley, C.J., Nie, S., Mobbs, G.W., Petrovic, S., Gres, A.T., Liu, X., Mukherjee, S., Harvey, S., Huber, F.M., Lin, D.H., Brown, B., Tang, A.W., Rundlet, E.J., Correia, A.R., Chen, S., Regmi, S.G., Stevens, T.A., Jette, C.A., Patke, A., Dasso, M., Palazzo, A.F., Kossiakoff, A.A., Hoelz, A.* (2022). Architecture of the cytoplasmic face of the nuclear pore.Science376, eabm9129.

Lin, D.H., Correia, A.C., Cai, S.W., Huber, F.M., Jette, C.A., Hoelz, A.* (2018). Structural and functional analysis of mRNA export regulation by the nuclear pore complex.Nat. Commun.9, 2319.

Lin, D.H.,# Stuwe, T.,# Schilbach, S., Rundlet, E.J., Perriches, T., Mobbs, G., Fan, Y., Thierbach, K., Huber, F.M., Collins, L.N., Davenport, A.M., Jeon, Y.E., Hoelz, A.* (2016). Architecture of the symmetric core of the nuclear pore.Science352, aaf1015. [Cover]

Stuwe, T.,# Bley, C.J.,# Thierbach, K.,# Petrovic, S.,# Schilbach, S., Mayo, D.J., Perriches, T., Rundlet, E.J., Jeon, Y.E., Collins, L.N., Huber, F.M., Lin, D.H., Paduch, M., Koide, A., Lu, V., Fischer, J., Hurt, E., Koide, S., Kossiakoff, A., Hoelz, A.* (2015). Architecture of the fungal nuclear pore inner ring complex.Science350, 56–64.

Stuwe, T.,# Correia, A.,# Lin, D.H., Paduch, M., Lu, V.T., Kossiakoff, A.A., Hoelz, A.* (2015). Architecture of the nuclear pore complex coat.Science347, 1148–1152.