Biotransformation Scientist

Scorpion Therapeutics; Missouri; On-site; USD 90,000 - 150,000; Full time

Job summary

Scorpion Therapeutics is seeking a Biotransformation Scientist to elucidate enzymatic drug metabolism pathways in preclinical models. This role focuses on identifying key enzymes that metabolize small molecules, peptides, and oligonucleotides, and establishing in vitro-to-in vivo relationships for drug clearance and half-life prediction.

The candidate will design LC-MS/MS and HRMS assays, characterize drug disposition mechanisms, and collaborate with pharmacology and toxicology teams to develop

Qualifications

• PhD with 2–5 years postdoc OR MSc with 5–7 years biotransformation experience.
• Expertise in contemporary bioanalytical techniques, enzyme kinetics, and MS data analysis.

Responsibilities

• Design and execute LC-MS/MS and HRMS-based assays.
• Characterize drug disposition mechanisms.
• Collaborate with pharmacology and toxicology teams to develop cellular models and platform screening methods.

Skills

Biotransformation

Enzyme kinetics

Mass spectrometry data analysis

Education

PhD in Chemistry/Biochemistry/Analytical Chemistry

MSc in a related field with 5–7 years biotransformation experience

Tools

LC-MS/MS

HRMS

In vitro ADME

Job description

Role: Biotransformation Scientist focusing on elucidating enzymatic drug metabolism pathways in preclinical models.

Primary objectives include identifying key enzymes involved in metabolizing small molecules, peptides, and oligonucleotides, and establishing in vitro-to-in vivo relationships for drug clearance and half-life prediction.

Responsibilities encompass designing and executing LC-MS/MS and HRMS-based assays, characterizing drug disposition mechanisms, and collaborating with pharmacology and toxicology teams to develop cellular models and platform screening methods.

Requirements: PhD in Chemistry, Biochemistry, or Analytical Chemistry with 2-5 years (postdoctoral) or MSc with 5-7 years biotransformation experience; expertise in contemporary bioanalytical techniques, enzyme kinetics, and mass spectrometry data analysis.

High-value: focus on small molecule, peptide, and oligonucleotide therapeutics, employing in vitro/in vivo ADME studies, with a particular emphasis on drug clearance mechanisms and metabolite structure elucidation.

The role involves laboratory-based research in a regulated environment, potentially exposing individuals to hazardous materials.

The position may be offered at different seniority levels based on experience and education.

Work setup: typical laboratory environment, with safety precautions due to chemical and biological hazards.