Biostatistics Director (Hybrid)

Vertex Pharmaceuticals Incorporated; Boston (MA); On-site; USD 196,000 - 294,000; Full time

Job summary

Vertex Pharmaceuticals is seeking a Director of Biostatistics to lead cutting-edge medical research within the Immunotherapies program. This hybrid role focuses on advanced statistical functions, project oversight, and the strategic collaboration necessary to support novel drug development. The ideal candidate will have a Ph.D. in Statistics or Biostatistics, extensive experience, and a passion for driving innovative healthcare solutions.

Benefits

Generous paid time off

Educational assistance programs

401(k) with contributions

Commuting subsidy

Annual bonus eligibility

Qualifications

• Typically requires 10 years of experience with a Ph.D.
• Demonstrated expertise in advanced statistical methods used in drug development.

Responsibilities

• Directs multiple clinical trials and observational studies.
• Authors study Statistical Analysis Plans and collaborates with cross-functional teams.
• Leads innovative designs and participates in discussions with regulators.

Skills

Project management

Expertise with SAS

Expertise with R

Critical thinking

Logical problem-solving

Communication skills

Education

Ph. D. in Statistics or Biostatistics

Job description

Job Description

General Summary:

As a Director Biostatistics at Vertex, you will be at the forefront of cutting-edge medical research, analyzing complex data to unravel crucial insights that may lead to innovative medical breakthroughs.

The Biostatistics Director will independently perform highly scientific statistical functions in support of the company's Immunotherapies program area on new and complex issues, creating alternative approaches to achieve desired results if needed. In addition, the Director provides independent strategic and technical contributions. The incumbent should possess an excellent knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset.

This position is hybrid, with a work schedule that allows for 2 days per week remote-based work and 3 days per week in the Boston Seaport office. (Relocation assistance is available).

Key Duties and Responsibilities:

• Directs one or more projects including multiple clinical trials, observational studies, or real world data (RWD) investigations. Also includes presentation to the Peer Protocol Review Committee (PPRC) or other internal senior review boards.
• Mentors project team members and promotes effective team operation and cross-functional collaboration.
• Possesses an expert understanding of modern drug discovery and development processes.
• Represents Biostatistics as a member of cross functional teams, providing strategic input and expert technical guidance to elicit meaningful and/or productive outcomes. Sets the technical and scientific directions of the project(s).
• Authors study Statistical Analysis Plans (SAPs), including table, figure, and listing (TFL) shells. Develops Cross-functional Data Review (xFDR) plan, Key Reports Memo (KRM), and Data Dissemination Plan (DDP) to facilitate the review, summary, and dissemination of key study data/results.
• Leads collaboration with statistical programming and other functions to ensure high quality and technically sound delivery of TFLs.
• Leads or contributes to external interactions with regulators, payers, review boards, etc.
• Authors or co-authors methodological or study-related publications and posters.
• Leads implementation of innovative designs and analysis methods at the study or project level and participates in Statistical Review Forum (SRF) discussions of studies assigned to others.
• Contributes to departmental working group efforts on key various technical and operational issues.
• Independently undertakes new and highly complex issues requiring advanced analytical thought.
• Completes work in a resourceful, self-sufficient manner; conceptualizes alternative, and at times untested, approaches to achieve desired results.
• Maintains and expands in-depth knowledge of related disciplines with a drug developer mindset.

Knowledge and Skills:

• Project management and project team oversight
• Expertise with SAS and R statistical software
• Demonstrated expertise in advanced/complex statistical methods used in drug development
• Deep skill in critical thinking and logical problem-solving
• Excellent written and verbal communication skills with the ability to influence opinions of peers and managers
• Excels in a team environment
• Collaborates well with non-statisticians and can effectively explain complex concepts to non-technical audiences
• NDA/MAA experience and direct dealings with USA/European regulators.

Education and Experience:

• Ph. D. in Statistics or Biostatistics.
• Typically requires 10 years of experience with a Ph.D.

#LI-AR1

#LI-Hybrid

Pay Range:

$196,000 - $294,000

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]