Biostatistician: AI-Driven Clinical Trials & Digital Twins

Unlearn; San Francisco (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Equity participation

Medical/dental/vision insurance

401k with matching

Flexible PTO

Company holidays

Commuter benefits

Paid parental leave

Job summary

Unlearn, based in San Francisco, is seeking a Biostatistician to lead integration of state‑of‑the‑art ML approaches into design and analysis of clinical trials. This role emphasizes practical autonomy and collaboration across customers and internal teams.

Candidates will have 2+ years in pharma/biotech, an MS/PhD in Statistics or Biostatistics, and proficiency in SAS and R; experience with SAPs, regulatory docs, and trial design is highly valued.

Qualifications

• At least 2 years of experience at a pharmaceutical/biotech company or CRO supporting clinical trials.
• MS or PhD in Statistics or Biostatistics.
• Experience writing statistical analysis plans and collaborating with clinical leaders.
• Strong knowledge of SAS and R.
• Experience in clinical trial design and optimization in both placebo controlled and hybrid study designs.

Responsibilities

• Define statistical analyses to utilize digital twins to improve power and lower sample size requirements of RCTs and to provide a comparator for single‑arm trials.
• Carry out internal and external case studies to utilize ML‑based predictions in clinical trial applications.
• Work with customers in trial planning applications to use digital twins to select and optimize inclusion/exclusion criteria, endpoints, and simulate trial outcomes.
• Author regulatory documents such as SAP and protocol sections or briefing book contributions for clinical trials that use digital twins.
• Present to clients and prospective clients on statistical methodology using digital twins and results of analyses, and represent Unlearn to the broader scientific community.
• Collaborate with internal teams to develop evidence and test methodologies.

Skills

SAS

R

Statistical analysis plans

Clinical trial design

Education

MS or PhD in Statistics or Biostatistics

Tools

SAS

R

Job description

Unlearn, based in San Francisco, is seeking a Biostatistician to lead integration of state‑of‑the‑art ML approaches into design and analysis of clinical trials. This role emphasizes practical autonomy and collaboration across customers and internal teams.

Candidates will have 2+ years in pharma/biotech, an MS/PhD in Statistics or Biostatistics, and proficiency in SAS and R; experience with SAPs, regulatory docs, and trial design is highly valued.