Biophysics Scientist

Amgen Inc. (IR); Thousand Oaks (CA); On-site; USD 111,000 - 150,000; Full time

Benefits offered by this job

Total Rewards Plan

Flexible work models where possible

Retirement and Savings Plan

Medical, dental, and vision coverage

Stock-based long-term incentives

Time-off plans

Job summary

Amgen Inc. (IR) in Thousand Oaks, California, seeks a Biophysics Scientist to advance discovery of innovative biological therapeutics using state-of-the-art SPR and cross-functional collaboration.

You will generate and analyze binding data, work with computational sciences to develop ML/AI models, and contribute to a dynamic team focused on translational science. The role requires advanced degrees and strong communication skills, with opportunities to contribute to a broad pipeline and

Qualifications

• Doctorate degree (PhD/MD/PharmD) or Master’s + 3 years scientific experience or Bachelor’s + 5 years scientific experience.
• Experience in binding analysis using SPR and characterization of binding across species.
• Strong communication skills and ability to work across teams.

Responsibilities

• Using SPR instruments to perform high throughput binding affinity characterization for biologics.
• Determine cross-species selectivity and study mechanism of action related to binding.
• Generate and analyze scientific data; communicate results orally and in writing.
• Collaborate with scientists across functions.
• Interface with Computational Sciences to develop ML/AI models improving molecular attributes.

Skills

Biophysics

Protein chemistry

Cell biology

Lab automation

Communication

Multi-tasking

Education

PhD in related field

MD/PharmD considered

Bachelor's + 5 years experience

Tools

Surface Plasmon Resonance (SPR)

Bravo

Hamilton

Job description

Career Category Scientific Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Biophysics Scientist

What you will do

Let’s do this. Let’s change the world. In this vital role you will be a member of a team involved in the discovery of innovative biological therapeutics. This team is applying state-of-art experimental technologies that are transforming the way we discover and develop new medicines for our patients.

Key Responsibilities

• Using state-of-the-art Surface Plasmon Resonance (SPR) instruments, you will implement and execute high throughput binding affinity characterization on biologics from generative biology, which plays a critical role in Amgen’s drug discovery pipeline.
• In addition to affinity characterization, you will be expected to determine cross-species selectivity and implement experiments to study mechanism of action when related to binding interactions.
• You should be meticulous and proficient in generating and analyzing scientific data, and will be expected to communicate the results clearly, both orally and in written form.
• You will be able to work collaboratively with other scientists, within and across functions.
• You will be expected to interface with our Computational Sciences Group to develop ML/AI models that improve molecular attributes, such as binding activities.

What we expect of you

Basic Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] OR Master’s degree and 3 years of scientific experience OR Bachelor’s degree and 5 years of scientific experience

Preferred Qualifications

• Knowledge in protein chemistry, cell biology, biophysics, and experience in binding analysis using Surface Plasmon Resonance (SPR). Demonstrated excellent laboratory working ethic and skills, excellent communication skills (both written and oral). Demonstrated flexibility, ingenuity, and problem-solving capability, as well as a strong ability to multi-task. Hands-on experience in lab automation, such as Bravo, Hamilton, biochemical and cellular assays using advanced instruments. Knowledge and hands-on experience in membrane protein generation and characterization are highly desirable. Demonstrated capabilities of bridging experimentation with computational modeling and ML activities.

What you can expect from us

From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Equal Opportunity Employer

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Salary Range

Salary Range 110,971.75USD -150,138.25 USD

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

For more information, visit www.amgen.com and follow us on www.twitter.com/amgen