Biologist in Immunology Discovery Research

BioSpace; Indianapolis (IN); On-site; USD 66,000 - 172,000; Full time

Job summary

Lilly's Immunology Discovery Research group in Indianapolis, IN is seeking a scientist to design and validate immunology cell-based assays that generate preclinical data for future therapeutics. You will work with human, monkey, and mouse lymphocytes, applying techniques like flow cytometry, ELISA, and qPCR in a collaborative, fast-paced environment.

The role requires a BS/MS in biology with 2–3 years of experience, strong immunology background, and experience with multi-color flow cytometry.

Qualifications

• B.S or M.S. in biology or related area with 2–3 years of work experience.
• Research experience in immunology and molecular biology; purification/handling primary human lymphocytes desirable.
• Basic understanding of high-parameter multi-color flow cytometry desirable.

Responsibilities

• Design, develop and validate immunology cell-based functional assays to deliver preclinical data.
• Isolate, purify and culture human, non-human primate and mouse lymphocytes for in vitro assays.
• Develop cellular activity assays using Western blot, qPCR, intracellular staining and phospho-flow cytometry.
• Investigate cytokine signaling and mechanism of action of biologics and small molecules.
• Perform siRNA knockdown and transfection in cell lines and primary cells; analyze and present data.

Skills

Immunology knowledge

Cell-based assays

Flow cytometry

Data analysis

Independent experiments

Education

B.S./M.S. in biology

Tools

Western blot

qPCR

ELISA

MSD multiplex

Confocal imaging

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work-but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Organization Overview

The Eli Lilly Immunology Discovery Research group focuses on discovering innovative medicines for treating immunological diseases. We are seeking a highly motivated and dedicated scientist with knowledge of cellular and molecular immunology, who also shares our passion to help patients live with higher quality of life.

Responsibilities

The successful candidate will report to a Ph.D senior scientist in the group located at Lilly in Indianapolis, IN and work in a highly team-oriented and collaborative environment. The successful candidate will need to be able to work independently to design, develop and validate immunology cell-based functional assays with the goal to deliver preclinical data to support novel therapeutics for future clinical testing, and to investigate the mechanism of action of biological and small molecule therapeutics.

• Develop immune functional cell-based assays using extensive immunology research-related technologies (e.g. primary lymphocytes from human, monkey, and mouse, cytokine assays, multi-color flow cytometry)
• Screen and analyze data for protein or small molecule drugs in cell-based assays
• Isolate, purify, and culture human, monkey, and mouse lymphocytes for in vitro assays with attention to detail and sterile technique
• Develop cellular activity assays using techniques such as western blot, qPCR, intracellular staining, phospho flow cytometry, confocal/imaging related techniques, ligand-binding assays like ELISA and MSD multiplex
• Investigate cellular signal transduction including cytokine/receptor signaling
• Perform and evaluate functional effects of siRNA mediated gene knockdown and transfection/transduction mediated gene expression in cell lines and primary human cells
• Independently design and execute experiments, troubleshoot, analyze, interpret and present experimental data
• Adhere to good research practices and timely, thorough laboratory e-notebook maintenance

Basic Requirements

• B.S or M.S. in biology, molecular and cellular immunology or a related biological area with 2-3 years of work experience in an academic institute or pharmaceutical industry
• Research experience in immunology and molecular biology. Previous experience in purification and handling primary human lymphocytes (and other species) is highly desirable.
• Basic understanding of and previous experience with high-parameter multi-color flow cytometry is highly desirable.

Role

Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.

Additional Information

This position will be located at Lilly Corporate Center, Indianapolis, IN.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women's Initiative for Leading at Lilly (WILL).

Actual Compensation

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is

$66,000 - $171,600

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).

In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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