Biologics Downstream Processing Scientist II

Merck & Co.; Waltham (MA); On-site; USD 113,600 - 163,300; Full time

Benefits offered by this job

Paid time off

Health benefits

Retirement plans

Job summary

Merck & Co. in the United States is seeking a Scientist II, Downstream Processing to independently design, execute, and interpret studies testing prototype downstream technologies for biologics and advanced therapies.

You will generate application data across mAbs, recombinant proteins, and vaccines, translating results into actionable technical recommendations and customer materials. The role requires hands‑on lab execution, collaboration with product development and field teams, and clear

Qualifications

• Ph.D. in chemical engineering or related field with 2+ years of experience; or M.S. with typically 5+ years; or B.S. with typically 8+ years of industry experience.
• Strong understanding of downstream processing technologies including chromatography, filtration, and ultrafiltration/diafiltration.
• Hands‑on experience with basic downstream analytical assays and characterization methods (ELISA, HPLC, SEC‑MALS, SDS‑PAGE).
• Ability to independently design and execute experiments and communicate recommendations clearly.
• Experience analyzing bioprocessing technology or equipment in industrial biotech or biopharma environments preferred.

Responsibilities

• Design, plan, and execute lab studies to test downstream processing technologies and products.
• Generate application data and technical insights for downstream workflows focusing on chromatography and TFF.
• Operate and troubleshoot AKTA chromatography systems and lab‑scale TFF systems.
• Analyze data, interpret performance, and translate findings into reports and recommendations.
• Collaborate with product development and field teams to support readiness and adoption of new technologies.
• Publish and present findings through publications, conferences, posters, and webinars.

Skills

Downstream processing

Chromatography

AKTA systems

Lab execution

Data analysis

Cross-functional collaboration

Technical communication

Education

Ph.D. in chemical engineering or related

M.S. in related field

B.S. in related field

Tools

ELISA

HPLC

SEC‑MALS

SDS‑PAGE

Job description

Merck & Co. in the United States is seeking a Scientist II, Downstream Processing to independently design, execute, and interpret studies testing prototype downstream technologies for biologics and advanced therapies.

You will generate application data across mAbs, recombinant proteins, and vaccines, translating results into actionable technical recommendations and customer materials. The role requires hands‑on lab execution, collaboration with product development and field teams, and clear