Senior Downstream Purification Scientist

Merck; Rahway (NJ); On-site; USD 173,000 - 273,000; Full time

Job summary

Merck is seeking a Principal Scientist to lead downstream processing of biologics within Rahway, NJ, driving purification strategies that enable rapid, robust development. You will design scalable processes, collaborate with cross‑functional teams across Discovery, Pre-clinical, Early Development, and Manufacturing, and guide projects toward regulatory readiness.

You will mentor scientists, foster innovation in continuous biomanufacturing, and contribute to strategy and execution of our

Qualifications

• Strong fundamental knowledge in downstream processing of biologics, with focus on purification and process development.
• Experience directing design, execution, analysis, and documentation of purification development.
• Track record of peer‑reviewed publications and presentations in downstream bioprocessing.

Responsibilities

• Shape and realize innovation across Biologics pipeline and strategy.
• Collaborate with cross‑functional teams to advance pipeline development.
• Develop robust scalable purification processes for biologics in various clinical stages.
• Improve downstream processes for cost efficiency and performance.
• Mentor staff and build collaborative teams; champion compliance and safety.

Skills

Biomanufacturing

Bioprocess Engineering

Cell Culture Process Development

Data Analysis

Regulatory Filings

Process Characterization

Protein Expression

Quality by Design

Strategic Initiative

Leadership Mentoring

Manufacturing Operations

Education

Ph.D. with 6+ years in Chemical/Biochemical engineering

MS with 8+ years

BS with 10+ years

Tools

None specified

Job description

Merck is seeking a Principal Scientist to lead downstream processing of biologics within Rahway, NJ, driving purification strategies that enable rapid, robust development. You will design scalable processes, collaborate with cross‑functional teams across Discovery, Pre-clinical, Early Development, and Manufacturing, and guide projects toward regulatory readiness.

You will mentor scientists, foster innovation in continuous biomanufacturing, and contribute to strategy and execution of our